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主要文件

安全信息

T9777

Sigma-Aldrich

Trypsin-chymotrypsin inhibitor

lyophilized powder

别名:

Bowman-Birk抑制剂

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10 G
¥2,729.29
25 G
¥6,300.78

¥2,729.29


国内现货,预计发货时间2025年4月24日详情



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10 G
¥2,729.29
25 G
¥6,300.78

About This Item

CAS号:
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.77

¥2,729.29


国内现货,预计发货时间2025年4月24日详情


产品名称

胰蛋白酶-胰凝乳蛋白酶抑制剂 来源于大豆, lyophilized powder

生物来源

Glycine max (soybean)

质量水平

表单

lyophilized powder

组成

Protein, 70-90% biuret

储存温度

2-8°C

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此商品
529257192066529265
density

1.15 g/mL at 25 °C (lit.)

density

1.15 g/mL at 25 °C (lit.)

density

1.15 g/mL at 25 °C (lit.)

density

1.15 g/mL at 25 °C (lit.)

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

product line

BioReagent

product line

-

product line

-

product line

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

solubility

ethanol: 120 mg/mL

solubility

-

solubility

-

solubility

-

一般描述

Bowman-Birk抑制剂通过七个二硫键进行高度的交联,具有胰蛋白酶和胰凝乳蛋白酶抑制的空间上不同的结构域。
糜胰蛋白酶抑制剂属于植物蛋白酶抑制剂家族。它主要存在于豆类(Fabaceae)和谷物类(Poaceae)。糜胰蛋白酶抑制剂中保守的半胱氨酸残基之间有多个二硫键,可维持抑制环的结构稳定性和活性构象。[1]糜胰蛋白酶具有抗癌性质。[2]

应用

Bowman Birk蛋白酶抑制剂可通过减少不正确的DNA修复来防止辐射诱导的癌症生成,从而减少双着丝粒染色体的数量。
来源于大豆的糜胰蛋白酶抑制剂已被用于流式细胞术分离酶活性检测。[3]它还被用于体外胃肠道 (GI) 消化研究,用于抑制I胰蛋白酶和糜蛋白酶。[4]

单位定义

在25℃、pH 7.6条件下,以BAEE为底物,一单位胰蛋白酶 = 每分钟产生0.001的ΔA253。反应体积 = 3.2 mL(1 cm光程)。

外形

含有pH7.6磷酸缓冲盐的冻干粉

分析说明

1 mg蛋白可抑制≥0.5 mg具有每mg蛋白~10,000 BAEE活性的胰蛋白酶,或≥1.0 mg具有每mg蛋白~40 BTEE的糜蛋白酶。

其他说明

查看更多关于 胰蛋白酶抑制剂的信息。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品
  • 技术规格说明书

  • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    访问文档库

    The Bowman-Birk inhibitor from soybeans as an anticarcinogenic agent
    Kennedy AR
    American Journal of Clinical Nutrition, 68(6), 1406S-1412S (1998)
    Alfonso Clemente et al.
    Molecular nutrition & food research, 54(3), 396-405 (2009-11-04)
    Bowman-Birk inhibitors (BBI) from soybean and related proteins are naturally occurring protease inhibitors with potential health-promoting properties within the gastrointestinal tract. In this work, we have investigated the effects of soybean BBI proteins on HT29 colon adenocarcinoma cells, compared with
    Yu Liu et al.
    Viruses, 10(10) (2018-10-17)
    The Bowman‒Birk inhibitor (BBI), a protease inhibitor derived from soybeans, has been extensively studied in anti-tumor and anti-inflammation research. We recently reported that BBI has an anti-HIV-1 property in primary human macrophages. Because HSV-2 infection plays a role in facilitating
    Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS
    Ruppenthal S, et al.
    PLoS ONE, 13(1), e0191734-e0191734 (2018)
    Evidence for ancient origins of Bowman-Birk inhibitors from Selaginella moellendorffii
    James AM, et al.
    Plant Cell, 29(3), 461-473 (2017)

    商品

    Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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