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Merck
CN

T9283

Anti-Tropomyosin (Sarcomeric) antibody, Mouse monoclonal

clone CH1, purified from hybridoma cell culture

别名:

Monoclonal Anti-Tropomyosin (Sarcomeric) antibody produced in mouse, Anti-C15orf13, Anti-CMD1Y, Anti-CMH3, Anti-HEL-S-265, Anti-HTM-alpha, Anti-LVNC9, Anti-TMSA

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00149029
Conjugate:
unconjugated
Clone:
CH1, monoclonal
Application:
ARR, IHC (f), IHC (p), IP, WB
Citations:
57

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biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

CH1, monoclonal

contains

15 mM sodium azide

species reactivity

human, chicken, rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50 using sections of human tongue, immunohistochemistry (frozen sections): suitable using human and animal tissue sections, immunoprecipitation (IP): suitable, microarray: suitable, western blot: suitable using native preparations

isotype

IgG1

UniProt accession no.

P09493

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

chicken ... TPM1(396366)
human ... TPM1(7168)
rat ... Tpm1(24851)

General description

Tropomyosin 1 (TPM1) is encoded by the gene mapped to human chromosome 15q22.2. The encoded protein belongs to the TPM protein family.

Immunogen

chicken muscle tropomyosin.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Monoclonal Anti-Tropomyosin (sarcomeric) antibody produced in mouse has been used in immunofluorescence and immunohistochemistry.

Biochem/physiol Actions

The antibody recognizes an epitope on skeletal and cardiac tropomyosin. The antibody shows no reaction with denatured protein by immunoblotting. No cross-reactivity has been observed with smooth muscle or non-muscle tropomyosin.
Tropomyosin 1 (TPM1) is a potent tumor suppressor gene. It is expressed at low levels in various types of solid cancers including, oral squamous cell carcinoma (OSCC) and tongue squamous cell carcinoma. Mutation in the gene is associated with the development of hypertrophic cardiomyopathy. The encoded protein is involved in the regulation of actin-myosin interaction in striated muscles. Tropomyosin plays an essential role in Ca2+ -regulated contraction of cardiac muscle.

Physical form

Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

动植物来源生物产品
常规特殊物品
常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000512419
0000512419
0000442799
0000442799
0000405460

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Coarctation of the aorta and mild to moderate developmental delay in a child with a de novo deletion of chromosome 15(q21.1q22.2).
Lalani SR
BMC Medical Genetics (2006)
Maria E Baardman et al.
Disease models & mechanisms, 9(4), 413-425 (2016-01-30)
Lipoprotein-related receptor protein 2 (LRP2) is important for development of the embryonic neural crest and brain in both mice and humans. Although a role in cardiovascular development can be expected, the hearts ofLrp2knockout (KO) mice have not yet been investigated.
Structural and Functional Effects of Cardiomyopathy-Causing Mutations in the Troponin T-Binding Region of Cardiac Tropomyosin.
Matyushenko AM
Biochemistry, 56, 250-259 (2017)
Effect of Cardiomyopathic Mutations in Tropomyosin on Calcium Regulation of the Actin-Myosin Interaction in Skeletal Muscle.
Kopylova GV
Bulletin of experimental biology and medicine, 162, 42-44 (2016)
Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma
Pan H
PLoS ONE, 12, e0168900-e0168900 (2017)
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