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质量水平
检测方案
≥99%
溶解性
H2O: soluble 250 mg plus 5 ml of solvent, clear, colorless to faintly yellow
chloroform: soluble
diethyl ether: insoluble
ethanol: soluble
methanol: soluble
SMILES字符串
Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1
InChI
1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
InChI key
NZFNXWQNBYZDAQ-UHFFFAOYSA-N
基因信息
human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)
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应用
盐酸噻哒嗪已被用作嵌入剂，使用方波伏安法（SWV）技术分析双链DNA（dsDNA）的完整性。盐酸噻哒嗪还被用作抑制人肝微粒体中肝酶细胞色素P4502D6（CYP2D6）的阳性对照。
生化/生理作用
D2 多巴胺受体拮抗剂； 吩噻嗪类抗精神病药，减少锥体束外副作用； Ca2+ 通道阻滞剂。
制备说明
250 mg盐酸硫代哒嗪可溶于5 ml水中，生成透明、无色至微黄色溶液。盐酸噻哒嗪也可溶于甲醇、乙醇和氯仿，但不溶于乙醚。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
H K Crewe et al.
British journal of clinical pharmacology, 34(3), 262-265 (1992-09-01)
Inhibition of human cytochrome P4502D6 (CYP2D6)-catalysed metabolism can lead to clinically significant alterations in pharmacokinetics. Since there is evidence that the selective serotonin reuptake inhibitor (SSRI) class of antidepressant drugs might inhibit CYP2D6, the effects of five SSRIs on human
Michael Stenger et al.
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The rise in antimicrobial resistance is a major global concern and requires new treatment strategies. The use of helper compounds, such as thioridazine (TDZ), an antipsychotic drug, in combination with traditional antibiotics must be investigated. The aim of this study
Evaluation of damage to DNA induced by UV-C radiation and chemical agents using electrochemical biosensor based on low molecular weight DNA and screen-printed carbon electrode.
Hlavata, L., et al.
Electrochimica Acta, 71, 134-139 (2012)
J S Someren et al.
Biochemical and biophysical research communications, 260(3), 619-625 (1999-07-15)
We have shown that heat shock proteins (HSPs) associated with steroid receptor complexes are involved in the activation of calcineurin by aldosterone and dexamethasone. To determine whether HSPs directly interact with calcineurin, we measured the effect of HSPs 90, 70
M Ashkenazy-Shahar et al.
Molecular genetics and metabolism, 67(4), 334-342 (1999-08-13)
We studied here, in NIH-3T3 fibroblasts, the effect of the Ca(2+)-ionophore A23187 (which is known to increase intracellular-free Ca(2+)) on the control of glycolysis and cell viability and the action of calmodulin antagonists. Time-response studies with Ca(2+)-ionophore A23187 have revealed
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