T8951
桔皮素
≥95% (HPLC)
别名:
4′,5,6,7,8-五甲氧基黄酮, 5,6,7,8-四甲基-2-(4-甲氧基苯基)-4H-1-苯并吡喃-4-酮, NSC 53909, NSC 618905, 桔皮素
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经验公式（希尔记法）:
C20H20O7
化学文摘社编号:
分子量:
372.37
UNSPSC Code:
12352205
NACRES:
NA.25
PubChem Substance ID:
EC Number:
207-570-1
Beilstein/REAXYS Number:
351695
MDL number:
InChI
1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3
SMILES string
COc1ccc(cc1)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
InChI key
ULSUXBXHSYSGDT-UHFFFAOYSA-N
assay
≥95% (HPLC)
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
Quality Level
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General description
桔皮素是一种多甲氧基黄酮，主要从柑橘类水果的果皮中提取，如 甜橙 和 中国桔子。
Application
桔皮素已被用作抗氧化剂和抗真菌剂，用于测试其对 稻瘟病原菌的铁死亡抑制、分生孢子发育和附着胞形成的影响。它还被用作辅助化疗剂，以研究其与5-氟尿嘧啶(5-Fu)联合使用对WiDr结肠癌细胞的细胞毒性作用。
Biochem/physiol Actions
在 体外 和 体内 研究中，桔皮素通过调节几种癌症类型中的不同途径来发挥其抗癌作用。它还具有抗氧化、抗炎和雌激素特性。
桔皮素是一种在柑橘类水果皮中发现的黄酮类化合物，它最有可能对真菌产生天然抗性。 桔皮素已被证明可以抵消肿瘤启动子诱导的细胞间通讯抑制，并可抑制几种癌症细胞的细胞增殖。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Jérôme Quintin et al.
Bioorganic & medicinal chemistry letters, 19(1), 167-169 (2008-11-18)
A series of chalcones polyoxygenated on the ring A (with pentamethoxy or 2'-hydroxy-3',4',5',6'-tetramethoxy substitution patterns) was synthesized from tangeretin, a natural Citrus flavonoid. These chalcones were evaluated for their antiproliferative, activation of apoptosis, inhibition of tubulin assembly and antileishmanial activities.
Hideo Satsu et al.
Journal of agricultural and food chemistry, 56(13), 5366-5373 (2008-06-11)
The pregnane X receptor (PXR) is understood to be the key regulator for gene expression of such drug-metabolizing enzymes and transporters as multidrug-resistant protein 1 (MDR1) and the cytochrome P450 (CYP) family. We examined the effect of dietary phytochemicals on
Combination of Tangeretin and 5-Fluorouracil Modulates Cell Cycle and Induce Apoptosis on WiDr Cells
Indriyani L, et al.,
Indonesian Journal of Cancer Chemoprevention, 3(1), 364-369 (2012)
Hong-Yin Wu et al.
Journal of agricultural and food chemistry, 59(5), 1713-1722 (2011-02-15)
This study investigated the potential effects of natural products ursolic acid (UA) and oleanolic acid (OA) against HBx-mediated tumorigenic activities in vitro and in vivo. HBx transactivated Sp-1 and Smad 3/4 in Huh7 and FL83B hepatocytes and induced cell migration
John A Manthey et al.
Journal of agricultural and food chemistry, 59(1), 145-151 (2010-12-08)
Nobiletin (NOB) and tangeretin (TAN), two of the main polymethoxylated flavones (PMFs) in citrus, influence a number of key biological pathways in mammalian cells. Although the impacts of NOB and TAN on glucose homeostasis and cholesterol regulation have been investigated
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