T8885
Thrombin 来源于人类血浆
lyophilized powder, Suitable for routine use in the thrombin time test
别名:
IIa因子
产品名称
Thrombin 来源于人类血浆, lyophilized powder, Suitable for routine use in the thrombin time test
biological source
human plasma
form
lyophilized powder
packaging
vial of ≥10 NIH units
impurities
HIV, hepatitis B and hepatitis C, tested negative
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... F2(2147)
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Preparation Note
当使用1 ml H2O重悬时，一瓶含有10 mg牛血清白蛋白、0.15 M NaCl和0.05 M柠檬酸钠，pH 6.5
Analysis Note
NIH 试验步骤基于 Biggs 方法的改进，使用 0.2mL 稀释血浆（与生理盐水 1:1 混合，作为底物）和 0.1mL Biggs 凝血酶样品（稳定于 1% 缓冲白蛋白溶液中）。只使用 15-25 秒之间的凝血时间分析凝血酶浓度。
Application
凝血酶被用于重组融合蛋白的位点特异性切割，这些重组融合蛋白具有可接近的凝血酶识别位点以除去亲和标签。已有研究使用凝血酶比较了低分子量肝素（LMWH）与其他抗凝剂作为大型矫形手术的静脉血栓栓塞预防剂的疗效和安全性。
Biochem/physiol Actions
选择性裂解纤维蛋白原中 Arg-Gly 键形成纤维蛋白和纤维蛋白肽 A 和 B 的丝氨酸蛋白酶。
Disclaimer
供研究使用。在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
General description
凝血酶是止血过程中的最终凝血蛋白酶，可同时促进促凝血和抗凝血作用。
Other Notes
查看更多关于 凝血酶的信息， 请访问 www.sigma-aldrich.com/enzymeexplorer。
活性以 NIH 单位表示，通过与 NIH 凝血酶参考标准品的直接比较获得
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
高风险级别生物产品--人源产品
此项目有
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