推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
用途
sufficient for 10 blots
种属反应性
mammals
技术
immunohistochemistry (frozen sections): 1:1,000
indirect immunofluorescence: 1:1,000
western blot: 1:1,000 using rat brain lysates of PC-12 cells stimulated by okadaic acid
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
一般描述
酪氨酸羟化酶 (TH) 由定位于人染色体 11p15 的基因编码。TH 是四种相同亚基组成的四聚体，特征是含有一个调节、催化和四聚体化结构域。该酶利用酪氨酸、四氢生物蝶呤 (BH4) 和 O2 作为辅底物，并利用 Fe2+ 作为辅因子。
免疫原
从嗜铬细胞瘤中纯化并经SDS变性的大鼠酪氨酸羟化酶。
生化/生理作用
酪氨酸羟化酶 (TH) 催化儿茶酚胺神经递质生物合成的第一个限速步骤，即 L-酪氨酸转化为 L-多巴的过程。L-苯丙氨酸对 TH 的抑制作用可能在苯丙酮尿症中发挥关键作用，并可阻止去甲肾上腺素合成。TH 活性可通过磷酸化来调节。TH 表达下调与各种神经精神疾病有关，例如精神分裂症和帕金森病 (PD)。
目标描述
酪氨酸羟化酶（TH）可参与到苯丙氨酸向多巴胺的转化。它可催化儿茶酚胺生物合成途径的初始限速步骤。
外形
含有10mM HEPES，pH 7.5、150mM NaCl、100 μg/mL BSA和50%甘油的100 μL溶液。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
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