生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
2G10, monoclonal
形式
buffered aqueous solution
分子量
antigen ~50 kDa
种属反应性
human, mouse, rat
包装
antibody small pack of 25 μL
浓度
~1.0 mg/mL
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 0.25-0.5 μg/mL using PC12 cell extract
同位素/亚型
IgG2a
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TUBB3(10381)
mouse ... Tubb3(22152)
rat ... Tubb3(246118)
相关类别
一般描述
微管蛋白 β 3 III类（TUBB3）也称 β-微管蛋白III，由定位于人染色体16q24.3的基因编码。TUBB3蛋白表达仅限于神经元。
应用
小鼠抗β-微管蛋白III（神经元）单克隆抗体还可用于以下研究：
- 免疫荧光。
- 免疫细胞化学。
生化/生理作用
微管蛋白 β 3 III类（TUBB3）在神经系统发育和轴突导向中起着至关重要的作用。编码蛋白的基因发生突变会导致眼动障碍、3型先天性眼外肌纤维化（CFEOM3）和各种神经综合征。蛋白表达的改变会影响微管动力学和微管-驱动蛋白相互作用。在肿瘤组织中，TUBB3的表达上调。TUBB3的表达下调可以作为皮肤恶性黑素瘤预后不良的重要标志物。TUBB3参与抑制肿瘤组织的侵袭性生长；因此，它是开发抗肿瘤药物的潜在靶标。
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
其他说明
免责声明
除非我们的产品目录或产品随附的其他公司文档中另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人或动物。
Not finding the right product?
Try our 产品选型工具.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Zhiqiang Zheng et al.
PloS one, 5(9), e12555-e12555 (2010-09-15)
Embryonic stem (ES) cells hold considerable promise as a source of cells with therapeutic potential, including cells that can be used for drug screening and in cell replacement therapies. Differentiation of ES cells into the somatic lineages is a regulated
Li-Hua Sun et al.
Molecular neurodegeneration, 10, 36-36 (2015-08-12)
Previous studies have demonstrated that the trafficking defects of Nav1.1/Nav1.2 are involved in the dementia pathophysiology. However, the detailed mechanisms are not fully understood. Moreover, whether the impaired miRNAs regulation linked to dementia is a key player in sodium channel
Maysam Mansouri et al.
Nature communications, 7, 11529-11529 (2016-05-05)
Multigene delivery and subsequent cellular expression is emerging as a key technology required in diverse research fields including, synthetic and structural biology, cellular reprogramming and functional pharmaceutical screening. Current viral delivery systems such as retro- and adenoviruses suffer from limited
A Odawara et al.
Scientific reports, 6, 26181-26181 (2016-05-18)
The functional network of human induced pluripotent stem cell (hiPSC)-derived neurons is a potentially powerful in vitro model for evaluating disease mechanisms and drug responses. However, the culture time required for the full functional maturation of individual neurons and networks
Demethylation of specific Wnt/?-catenin pathway genes and its upregulation in rat brain induced by prenatal valproate exposure.
Wang Z
Anatomical Record (Hoboken, N.J. : 2007), 293(11), 1947-1953 (2010)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门