T8543
O-三环[5.2.1.0 2,6 ] 癸基-9-二硫代碳酸酯 钾盐
synthetic (organic), ≥95%, phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor, solid
别名:
D609
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关于此项目
经验公式（希尔记法）:
C11H15KOS2
化学文摘社编号:
分子量:
266.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106300
EC Number:
280-379-9
MDL number:
产品名称
O-三环[5.2.1.0 2,6 ] 癸基-9-二硫代碳酸酯 钾盐, ≥95%, solid
InChI key
IGULCCCBGBDZKQ-HJPGVBIPSA-M
InChI
1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);/q;+1/p-1/t6-,7?,8?,9-,10?;/m1./s1
SMILES string
[K]SC(=S)OC1CC2CC1C3CCCC23
biological source
synthetic (organic)
assay
≥95%
form
solid
color
off-white to yellow
solubility
H2O: soluble 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
acetone: easily soluble
diethyl ether: insoluble
hydrocarbons: insoluble
Quality Level
Application
D609已被用作小鼠骨髓衍生的单核细胞中磷脂酰胆碱特异性磷脂酶C（PC-PLC）抑制剂。据报道，D609可以显著降低载脂蛋白 E-/-小鼠中磷脂酰乙醇胺结合蛋白1（PEBP1）的水平升高。
Biochem/physiol Actions
D609可以阻止细胞中二酰基甘油（DAG）的产生。D609通过抑制磷脂酶C介导的磷脂酰胆碱和其他甘油磷脂中存在的磷酸酯键的水解而起作用。
磷脂酰胆碱特异性磷脂酶C (PLC)和HIV-1抑制剂。 黄原酸酯衍生物具有体外抗肿瘤活性。
Preparation Note
O-三环[5.2.1.02,6]癸-9-基二硫代碳酸酯或D609以50 mg / ml的速度溶于水，并产生透明至微浑浊，无色至浅黄色溶液。 它也可溶于丙酮。 但不溶于醚和烃。
由于可能发生酯交换反应，因此不应制备酒精溶液。 该产物在溶液中非常不稳定（在组织培养基中半衰期为1.5天），并且在pH低于6.0时容易水解。因此，应在使用前立即配制溶液，并且必须丢弃未使用的溶液。对于组织培养制剂，培养基应缓冲至pH 6.0-7.5。不得使用HEPES缓冲液，因为它会使本产品有毒。
由于可能发生酯交换反应，因此不应制备酒精溶液。 该产物在溶液中非常不稳定（在组织培养基中半衰期为1.5天），并且在pH低于6.0时容易水解。因此，应在使用前立即配制溶液，并且必须丢弃未使用的溶液。对于组织培养制剂，培养基应缓冲至pH 6.0-7.5。不得使用HEPES缓冲液，因为它会使本产品有毒。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ning Tang et al.
Journal of orofacial pain, 23(2), 167-173 (2009-06-06)
To evaluate possible effects of the intracerebroventricular (icv) injection of either O-Tricyclo [5.2.1.0(2,6)] dec-9-yl dithiocarbonate potassium salt (D609), a potent antioxidant and inhibitor of phosphatidylcholine specific phospholipase C (PtdCho-PLC) and acid sphingomyelinase (ASMase), or the spin trap/free radical scavenger N-tert-Butyl-alpha-phenylnitrone
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