推荐产品
质量水平
检测方案
≥99%
形式
powder
颜色
white to off-white
mp
243 °C (dec.) (lit.)
溶解性
ethanol: soluble 5 mg/mL
H2O: soluble 50 mg/mL, clear, colorless to yellow
DMSO: soluble
储存温度
−20°C
SMILES字符串
Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
InChI
1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H
InChI key
BXDAOUXDMHXPDI-UHFFFAOYSA-N
基因信息
human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)
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应用
三氟哌嗪二盐酸盐在培养的海兔神经元中已被用作钙调蛋白 激酶拮抗剂。三氟哌嗪二盐酸盐也已被用作小鼠十二指肠组织中的一种PMCA抑制剂，以阻断跨细胞活性钙流动。
三氟哌嗪二盐酸盐已被用于：
- 抑制网格蛋白依赖型内吞
- 作为培养的加州海兔神经元中的钙调蛋白激酶拮抗剂
- 作为小鼠十二指肠质组织质膜Ca2+-ATP酶 (PMCA) 抑制剂阻断跨细胞活性钙通道
生化/生理作用
三氟拉嗪二盐酸盐可用于治疗精神分裂、行为失常、严重焦虑、呕心和呕吐。
吩噻嗪类抗精神病药；D2多巴胺受体拮抗剂；抑制3′:5′-环核苷酸磷酸二酯酶的钙调蛋白依赖性刺激；抑制cAMP门控阳离子通道。
制备说明
在按需加热时，三氟拉嗪二盐酸盐可以50 mg/ml溶于水，产生澄清的无色至黄色溶液。它也可溶于DMSO和乙醇（5 mg/ml）。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system, Eyes
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
M Carballo et al.
The Journal of biological chemistry, 274(1), 93-100 (1998-12-29)
We describe here a specific calcineurin activity in neutrophil lysates, which is dependent on Ca2+, inhibited by trifluoroperazine, and insensitive to okadaic acid. Immunoblotting experiments using a specific antiserum recognized both the A and B chains of calcineurin. Neutrophils treated
Extractive spectrophotometric determination of chlorpromazine and trifluoperazine hydrochloride in pharmaceutical preparations
Hassouna MEM, et al.
Egyptian Journal of Forensic Sciences, 2(2), 62-68 (2012)
E C Samouilidou et al.
Life sciences, 62(1), 29-36 (1998-01-28)
This study was designed to examine the role of calcium in the ischemia-induced changes of calmodulin-stimulated Ca2+-ATPase activity of heart sarcolemma of dogs subjected to coronary artery ligation (90 min) and reperfusion (30 min). This was attained by the application
Uptake of polyphosphate microparticles in vitro (SaOS-2 and HUVEC cells) followed by an increase of the intracellular ATP pool size
Muller WEG, et al.
PLoS ONE, 12(12), e0188977-e0188977 (2017)
R L Mach et al.
Biochimica et biophysica acta, 1403(3), 281-289 (1998-08-01)
The addition of Ca2+-antagonizers (La2+), Ca2+-ionophores (A23187) and Ca2+-complexing agents (EGTA) inhibited the formation of xylanase activity in resting mycelia of Trichoderma reesei. The inhibition by the ionophore was reversed by the addition of Ca2+ ions. A similar inhibitory effect
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