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Merck
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安全信息

T7816

Sigma-Aldrich

单克隆抗 β-微管蛋白 I 小鼠抗

clone SAP.4G5, ascites fluid

别名:

Anti-CDCBM6, Anti-CSCSC1, Anti-M40, Anti-OK/SW-cl.56, Anti-TUBB1, Anti-TUBB5

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About This Item

MDL编号:
MFCD02095890
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

mouse

质量水平

200

偶联物

unconjugated

抗体形式

ascites fluid

抗体产品类型

primary antibodies

克隆

SAP.4G5, monoclonal

分子量

antigen ~55 kDa

种属反应性

Xenopus, chicken, human, hamster, canine, mouse, bovine, rat

技术

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:20,000 using cultured chicken fibroblasts

同位素/亚型

IgG1

UniProt登记号

P07437

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... TUBB(203068)
mouse ... Tubb4(22153)

相关类别

一般描述

微管蛋白是一种分子量为100 kDa 的蛋白，在所有细胞中以两种相似多肽α和ββ的异源二聚体形式存在并组装形成微管。微管的正确组装是细胞有丝分裂、减数分裂、某些形式的细胞器运动、细胞内转运、鞭毛运动和细胞骨架功能等多种细胞功能的必要基础。抗β-微管蛋白 I 单克隆抗体可用于 ELISA 定位β微管蛋白亚型 I，并可用于免疫印迹定位培养的人类和动物细胞。小鼠抗β-微管蛋白 I 抗体与人、大鼠、狗、牛、仓鼠、小鼠、鸡和爪蟾的β微管蛋白 C 末端序列中的表位发生特异性反应

特异性

识别一个位于 β-微管蛋白同种型 I 羧基端序列的表位。未观察到与其他微管蛋白同种型的反应。

免疫原

对应于 β-微管蛋白同种型 I 羧基端序列的合成肽，与 BSA 偶联。

应用

抗β-微管蛋白 I 单克隆抗体（稀释度1：4,000) 可用作免疫沉淀和免疫印迹中的一抗。它还可用于蛋白质印迹分析和逆转录病毒感染。

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Yosef Buganim et al.
Cancer research, 66(22), 10750-10759 (2006-11-17)
Mutations in p53 are ubiquitous in human tumors. Some p53 mutations not only result in loss of wild-type (WT) activity but also grant additional functions, termed "gain of function." In this study, we explore how the status of p53 affects
Richard G James et al.
PloS one, 7(12), e50457-e50457 (2012-12-12)
The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signaling, WIKI4. WIKI4 inhibits expression of ß-catenin target genes
Richard G James et al.
The Journal of biological chemistry, 288(48), 34658-34670 (2013-10-12)
Advances in phosphoproteomics have made it possible to monitor changes in protein phosphorylation that occur at different steps in signal transduction and have aided the identification of new pathway components. In the present study, we applied this technology to advance
Ohad Tarcic et al.
Cell reports, 14(6), 1462-1476 (2016-02-09)
Factors linking inflammation and cancer are of great interest. We now report that the chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B monoubiquitylation (H2Bub1), modulates inflammation and inflammation-associated cancer in mice and humans. Downregulation of RNF20 and H2Bub1 favors recruitment
M C Roach et al.
Cell motility and the cytoskeleton, 39(4), 273-285 (1998-05-15)
Tubulin, the subunit protein of microtubules, is an alpha/beta heterodimer. In many organisms, both alpha and beta consist of various isotypes. Although the isotypes differ in their tissue distributions, the question of whether the isotypes perform different functions in vivo
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