biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
SAP.4G5, monoclonal
mol wt
antigen ~55 kDa
species reactivity
Xenopus, chicken, human, hamster, canine, mouse, bovine, rat
technique(s)
immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1:20,000 using cultured chicken fibroblasts
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TUBB(203068)
mouse ... Tubb4(22153)
General description
微管蛋白是一种分子量为100 kDa 的蛋白,在所有细胞中以两种相似多肽α和ββ的异源二聚体形式存在并组装形成微管。微管的正确组装是细胞有丝分裂、减数分裂、某些形式的细胞器运动、细胞内转运、鞭毛运动和细胞骨架功能等多种细胞功能的必要基础。抗β-微管蛋白 I 单克隆抗体可用于 ELISA 定位β微管蛋白亚型 I,并可用于免疫印迹定位培养的人类和动物细胞。小鼠抗β-微管蛋白 I 抗体与人、大鼠、狗、牛、仓鼠、小鼠、鸡和爪蟾的β微管蛋白 C 末端序列中的表位发生特异性反应
Immunogen
对应于 β-微管蛋白同种型 I 羧基端序列的合成肽,与 BSA 偶联。
Application
抗β-微管蛋白 I 单克隆抗体(稀释度1:4,000) 可用作免疫沉淀和免疫印迹中的一抗。它还可用于蛋白质印迹分析和逆转录病毒感染。
Biochem/physiol Actions
识别一个位于 β-微管蛋白同种型 I 羧基端序列的表位。未观察到与其他微管蛋白同种型的反应。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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flash_point_f
Not applicable
flash_point_c
Not applicable
存储类别
12 - Non Combustible Liquids
法规信息
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动物来源生物产品
动物来源生物产品
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商品
Microtubules of the eukaryotic cytoskeleton are composed of a heterodimer of α- and β-tubulin. In addition to α-and β-tubulin, several other tubulins have been identified, bringing the number of distinct tubulin classes to seven.
Richard G James et al.
PloS one, 7(12), e50457-e50457 (2012-12-12)
The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signaling, WIKI4. WIKI4 inhibits expression of ß-catenin target genes
Yosef Buganim et al.
Cancer research, 66(22), 10750-10759 (2006-11-17)
Mutations in p53 are ubiquitous in human tumors. Some p53 mutations not only result in loss of wild-type (WT) activity but also grant additional functions, termed "gain of function." In this study, we explore how the status of p53 affects
M C Roach et al.
Cell motility and the cytoskeleton, 39(4), 273-285 (1998-05-15)
Tubulin, the subunit protein of microtubules, is an alpha/beta heterodimer. In many organisms, both alpha and beta consist of various isotypes. Although the isotypes differ in their tissue distributions, the question of whether the isotypes perform different functions in vivo
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T7816-.2ML | 04061837378652 |