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一般描述
2-硫脲嘧啶(2-Thiouracil)是尿嘧啶的硫代衍生物，是一种嘧啶核碱基。这种抗甲状腺药物在H2O &有机溶剂中的溶解度较低。
应用
2-硫脲嘧啶可用于：
- 银溶胶和膜基底的合成和表征，以及它们在表面增强拉曼光谱(SERS)中的应用。
- 研究其在二氧化钛(TiO2)纳米粒子改性金电极上的电氧化行为和测定方法
- 通过时间分辨光电子能谱研究甲基化对2-硫脲嘧啶的失活机制或三重态动力学的影响
生化/生理作用
2-硫尿嘧啶可作为抗癌、抗甲状腺和抗病毒剂。2-硫脲嘧啶是一种选择性黑色素瘤探测物和神经元一氧化氮合酶的竞争性抑制剂。可与金(Au)、铬(Cr)、锌(Zn)和银(Ag)等过渡金属形成络合物。2-硫脲嘧啶可加入组织培养基，在化疗期间抑制病毒复制或从感染组织转移到健康组织。
警示用语：
Warning
危险声明
危险分类
Carc. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Silver colloid and film substrates in surface-enhanced Raman scattering for 2-thiouracil detection
Al-Shalalfeh MM, et al.
Royal Society of Chemistry Advances, 6, 75282-75292 (2016)
A Palumbo et al.
FEBS letters, 485(2-3), 109-112 (2000-11-30)
2-thiouracil (TU), an established antithyroid drug and melanoma-seeker, was found to selectively inhibit neuronal nitric oxide synthase (nNOS) in a competitive manner (K(i)=20 microM), being inactive on the other NOS isoforms. The drug apparently interfered with the substrate- and tetrahydrobiopterin
K P Prasanthkumar et al.
The journal of physical chemistry. A, 116(44), 10712-10720 (2012-10-16)
The reaction of hydroxyl radical ((•)OH) with the nucleic acid base analogue 2-thiouracil (1) has been studied by pulse radiolysis experiments and DFT. The generic intermediate radicals feasible for the (•)OH reactions with 1, namely, one electron oxidation product (1(•+))
Raj Kumar Bera et al.
Chemical communications (Cambridge, England), 47(41), 11498-11500 (2011-09-22)
A nonenzymatic method for the selective detection and quantification of serum uric acid (UA) using 2-thiouracil (2-TU) tailored Au nanoparticles is developed. The H-bonding interaction of UA with functionalized Au nanoparticles brings instantaneous visible color change and paves the way
Julie A L Kiebooms et al.
Journal of agricultural and food chemistry, 60(32), 7769-7776 (2012-07-28)
In recent years, the frequent detection of the banned substance thiouracil (TU) in livestock urine has been related to its endogenous formation following consumption of glucosinolate-rich Brassicaceae crops. Besides, TU residues have been recovered in these crops upon plant-derived myrosinase
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