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Merck
CN

T7576

抗-TGN46 兔抗

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

抗-MGC14722, 抗-TGN38同源物, 抗-TGN48, 抗-TGN51, 抗-TGOLN2, 抗-TTGN2, 抗-反式高尔基体网络整合膜蛋白2前体, 抗-反式高尔基体网络蛋白2, 抗-反式高尔基体网络蛋白TGN51

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD09265378
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoprecipitation (IP)
indirect immunofluorescence
western blot (chemiluminescent)
Species reactivity:
human
Citations:
29
Technique(s):
immunoprecipitation (IP): 10-20 μg using TGN46 from human HepG2 cell lysates.
indirect immunofluorescence: 5-10 μg/mL using human A549 cells
western blot (chemiluminescent): 0.25-0.5 μg/mL using extracts of human HEK-293T cells expressing recombinant human TGN46
Uniprot accession no.:
O43493

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产品名称

抗-TGN46 兔抗, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 80-100 kDa

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1 mg/mL

technique(s)

immunoprecipitation (IP): 10-20 μg using TGN46 from human HepG2 cell lysates.
indirect immunofluorescence: 5-10 μg/mL using human A549 cells
western blot (chemiluminescent): 0.25-0.5 μg/mL using extracts of human HEK-293T cells expressing recombinant human TGN46

UniProt accession no.

O43493

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... TGOLN2(10618)

相关类别

Application

兔多克隆抗TGN46抗体可用于标记反式高尔基体网络蛋白2，并可通过免疫细胞化学和免疫组化（IHC）技术（例如免疫印迹、免疫沉淀和免疫荧光）进行检测和定量。它可作为探针，对反式高尔基网络蛋白2[作为反式高尔基网络（TGN）的膜转运调节成分]的存在和作用进行确定。抗TGN46可用作TGN标记。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。

General description

TGN46（反式高尔基体网络蛋白，46 kDa）是大鼠TGN38的人类同源物，是反式高尔基体网络（TGN）的固有整合膜蛋白，其可在TGN和质膜之间进行组成性循环，并通过内体返回。TGN是蛋白质分泌途径、脂质和膜运输的的主要分选细胞器。TGN46是一种高度糖基化的蛋白质，可能参与调节往返TGN的膜运输。TGN46包含信号肽、内腔结构域、跨膜结构域和胞质结构域。跨膜区域和胞质尾巴分别包含保留和回收信号，可用于TGN的定位。TGN46在细胞中广泛表达。
抗TGN46可识别人反式高尔基体网络蛋白2（TGN46）。通过免疫印迹对TGN46条带的检测可被免疫肽特异性抑制。

Immunogen

对应于人TGN46的氨基酸残基426-437的合成肽，N-末端添加有半胱氨酸，并与KLH偶联。与大鼠中的相应序列相同，与人的相应序列相差2个氨基酸。

Physical form

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000453503
0000453503
0000377806
0000377806
0000198758

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Andrea N Dietz et al.
Journal of virology, 92(1) (2017-10-20)
The human cytomegalovirus (HCMV) tegument protein pUL71 is required for efficient secondary envelopment and accumulates at the Golgi compartment-derived viral assembly complex (vAC) during infection. Analysis of various C-terminally truncated pUL71 proteins fused to enhanced green fluorescent protein (eGFP) identified
Jiehua Li et al.
Autophagy, 13(2), 345-358 (2016-11-23)
The membrane source for autophagosome biogenesis is an unsolved mystery in the study of autophagy. ATG16L1 forms a complex with ATG12-ATG5 (the ATG16L1 complex). The ATG16L1 complex is recruited to autophagic membranes to convert MAP1LC3B-I to MAP1LC3B-II. The ATG16L1 complex
Yong Yu et al.
The Biochemical journal, 434(3), 383-390 (2011-01-22)
Peptide hormones and neuropeptides are packaged and stored in a specialized intracellular organelle called the dense core vesicle. It remains elusive how peptide cargoes are correctly sorted. In the present study, we show that a highly conserved Golgi-localized protein named
Shuaizhi Li et al.
PloS one, 14(11), e0225496-e0225496 (2019-11-20)
Human papillomavirus (HPV) is the most common sexually transmitted pathogen in the United States, causing 99% of cervical cancers and 5% of all human cancers worldwide. HPV infection requires transport of the viral genome (vDNA) into the nucleus of basal
Federico Battisti et al.
Frontiers in immunology, 8, 1179-1179 (2017-10-11)
Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity. Albeit intensively investigated, the in vivo
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Data Sheet - T7576

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