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安全信息

T7154

Sigma-Aldrich

Tyr-Ile-Gly-Ser-Arg

≥97% (HPLC)

别名:

Laminin Fragment 929-933

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About This Item

经验公式（希尔记法）:
C26H42N8O8
CAS号:
110590-64-2
分子量:
594.66
MDL编号:
MFCD00076472
UNSPSC代码:
12352209
PubChem化学物质编号:
24900419
NACRES:
NA.32

生物来源

synthetic (organic)

质量水平

200

方案

≥97% (HPLC)

表单

powder

技术

cell culture | mammalian: suitable

溶解性

H2O: soluble 1 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1

InChI key

MWOGMBZGFFZBMK-LJZWMIMPSA-N

Amino Acid Sequence

Tyr-Ile-Gly-Ser-Arg

应用

Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.

生化/生理作用

Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.
Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.

制备说明

Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
0000261358
0000261358
SLCN4078
SLCL5444
SLCK3748

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Presenting multiple adhesion ligands on hydrogels for control of PC12 phenotype.
Jae-Won Lee et al.
Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1, e219-e220 (2011-12-27)
Yamato Kikkawa et al.
Cell adhesion & migration, 7(1), 150-256 (2012-12-25)
Laminin-111 is a large trimeric basement membrane glycoprotein with many active sites. In particular, four peptides active in tumor malignancy studies have been identified in laminin-111 using a systematic peptide screening method followed by various assays. Two of the peptides
Angelo Bella et al.
Journal of medicinal chemistry, 52(24), 7966-7969 (2009-12-03)
Conformationally constrained mimetics of the laminin cell-adhesion site, YIGSR, are described. The site is the natural antagonist of the integrin-associated laminin receptor 1 (LAMR1) known to mediate metastatic tumor adhesion. The attachment of selected metastatic cell lines toward the constrained
Bart G J Dekkers et al.
Respiratory research, 11, 170-170 (2010-12-07)
Fibroproliferative airway remodelling, including increased airway smooth muscle (ASM) mass and contractility, contributes to airway hyperresponsiveness in asthma. In vitro studies have shown that maturation of ASM cells to a (hyper)contractile phenotype is dependent on laminin, which can be inhibited
Amer F Alhaj Saleh et al.
Biopolymers, 89(1), 62-71 (2007-09-29)
Cell penetrating peptide based gene carriers are notably known for low level of gene transfer. To remedy this, as laminin receptor (LR) has been previously linked to tumor metastasis, the LR-binding domain (YIGSR) as well as a scrambled sequence (SGIYR)
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Conjugated Polymers for the Engineering of Device/Tissue Interface

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