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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white
溶解性
H2O: >20 mg/mL
创始人
Acorda Therapeutics
SMILES字符串
Cl[H].Clc1ccc2nsnc2c1NC3=NCCN3
InChI
1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
InChI key
ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
基因信息
human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
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应用
盐酸替扎尼定已被用于开发骨骼肌松弛剂验证的分光光度法。
生化/生理作用
已知盐酸替扎尼定可起到骨骼肌松弛剂中央的作用。此外，这种松弛剂可在脊柱和脊柱上水平起作用，以阻断兴奋性神经元。该药可用于缓解痉挛和疼痛性肌肉痉挛的症状。
α2-肾上腺素能受体激动剂。
特点和优势
该化合物由Acorda Therapeutics开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
制备说明
盐酸替扎尼定可以高于20 mg/ml的浓度溶于水。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Tomoyuki Kawamata et al.
Anesthesiology, 98(6), 1480-1483 (2003-05-27)
Although intrathecal clonidine produces pronounced analgesia, antinociceptive doses of intrathecal clonidine produce several side effects, including hypotension, bradycardia, and sedation. Intrathecal tizanidine, another alpha(2)-adrenergic agonist, has provided antinociception without producing pronounced hemodynamic changes in animal studies. However, it has been
Mohamed I Walash et al.
Chemistry Central journal, 5, 60-60 (2011-10-11)
A simple, sensitive and rapid spectrophotometric method was developed and validated for the determination of two skeletal muscle relaxants namely, tizanidine hydrochloride (I) and orphenadrine citrate (II) in pharmaceutical formulations. The proposed method is based on the formation of a
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