推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
种属反应性
rat, mouse, human
技术
microarray: suitable
western blot: suitable
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer199/pSer202)
基因信息
human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)
一般描述
Tau(τ)，别名MAPT（微管相关蛋白tau），由位于人染色体17q21.3上的基因编码。高度表达于神经元细胞，在轴突中浓度最高。
Tau蛋白属微管相关磷蛋白(MAP)，主要在中枢神经系统神经元中表达。在微管蛋白聚合中发挥重要作用，促进微管装配和稳定。tau蛋白的生物活性取决于其磷酸化程度。抗-磷酸化Tau(pSer199/202)抗体可用于微阵列和蛋白质印迹分析(western blotting)。还可用于免疫印迹分析。兔抗-磷酸化Tau (pSer199/202)抗体与人Tau (pSer199/202)(45-68 kD)特异性反应。
Tau蛋白属微管相关磷蛋白(MAP)，主要在中枢神经系统神经元中表达。在微管蛋白聚合中发挥重要作用，促进微管装配和稳定。tau蛋白的生物活性取决于其磷酸化程度。抗-磷酸化Tau(pSer199/202)抗体可用于微阵列和蛋白质印迹分析(western blotting)。还可用于免疫印迹分析。兔抗-磷酸化Tau(pSer199/202)抗体与人Tau (pSer199/202)(45-68 kD)特异性反应。
免疫原
化学合成人tau蛋白含丝氨酸199和丝氨酸202区域来源的磷酸肽。
应用
兔生产的抗-磷酸化Tau(pSer199/202)抗体已用于：
- 免疫细胞化学
- 免疫组织化学
- 蛋白质印迹(western blot)
抗-磷酸化Tau (pSer199/202)抗体（用含0.3% Triton X-100和0.5% BSA的PBS1:1000稀释）可用于通过免疫细胞化学法鉴定蛋白聚集体。还可作为一抗（1: 3000稀释）用于免疫组织化学分析。
生化/生理作用
Tau(τ)在微管结构的组装和维持中起着至关重要的作用。tau(τ)缺失会导致发育迟缓和学习困难。其基因表达与阿尔茨海默症(AD)的发展有关。τ基因变异会提高罹患散发性tau蛋白病(sporadic tauopathies)、进行性核上性麻痹(PSP)和皮质基底节变性的风险。
外形
溶于100 μl 杜氏磷酸盐缓冲液（不含Mg2+和Ca2+），pH 7.3，含50%甘油、1.0 mg/ml BSA（IgG，无蛋白酶）和0.05%叠氮化钠。本品的抗体量足够进行10次免疫印迹分析。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
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警示用语：
Warning
危险声明
预防措施声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
320.0 °F - closed cup
闪点(°C)
160 °C - closed cup
法规信息
含少量动物源组分生物产品
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