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Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
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主要文件

安全信息

T6515

Sigma-Aldrich

胆囊收缩素片段30-33酰胺

≥95% (HPLC)

别名:

CCK-4, Trp-Met-Asp-苯乙酰胺, 四胃泌素 盐酸盐, 胃泌素四肽

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About This Item

经验公式(希尔记法):
C29H36N6O6S
CAS号:
分子量:
596.70
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.32

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质量水平

方案

≥95% (HPLC)

表单

powder

分子量

59670 g/mol

技术

toxicology assay: suitable

溶解性

DMF: 20 mg/mL, clear, colorless to yellow

适用性

suitable for molecular biology

UniProt登记号

储存温度

−20°C

SMILES字符串

CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O

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此商品
852245852246852233
form

solid

form

powder

form

powder

form

powder

functional group

Fmoc

functional group

Fmoc

functional group

Fmoc

functional group

hydroxyl

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

storage temp.

15-25°C

storage temp.

15-25°C

storage temp.

15-25°C

storage temp.

2-30°C

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

200

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Amino Acid Sequence

Trp-Met-Asp-Phe-NH2

一般描述

研究领域:神经科学

大脑中具有神经肽胆囊收缩素(CCK)的多个生物活性片段,它们在大脑中与CCK-A和 CCK-B受体相互作用。 在这些片段中,CCK-4在皮层和脑边缘系统中含量特别丰富。[1]作为胆囊收缩素的生物活性形式,CCK-4是一种肽激素,通过结合肠道和脑中的CCK受体来调节食物摄入。[2]

应用

胆囊收缩素片段 30-33 酰胺可用于灭活 CCK8 抗血清。[3] 该产品也可用作吸收控制中的抗原,用于测试抗血清的特异性。[4]胆囊收缩素片段 30-33 酰胺用于诱导小鼠中的抗焦虑和抗抑郁作用,并用于研究神经肽Y的作用。[1]

生化/生理作用

胆囊收缩素片段 30-33 酰胺也称为 CCK-4 或 Trp-Met-Asp-Phe 酰胺是衍生自肽激素胆囊收缩素的肽片段。CCK-4 是引起人惊恐发作的惊恐试剂。化合物的这种性质可用于测试新抗焦虑药的科学研究。[5]CCK-4 通过CCK-B受体选择性地起作用,其在情绪性行为调节中的作用得到广泛认可。 CCK 敲低小鼠研究表明其具有抗焦虑和抗抑郁作用。[1]

包装

无底玻璃瓶。内含物装在插入的融合锥内。

制备说明

胆囊收缩素片段 30-33 酰胺溶于二甲基甲酰胺中,浓度为 20 mg/ml,得到澄清、无色至黄色的溶液。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品
  • 技术规格说明书

  • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    Andreas Ströhle et al.
    Journal of psychiatric research, 43(12), 1013-1017 (2009-03-18)
    Regular physical activity is anxiolytic in both healthy subjects and patients with panic disorder. In contrast, acute exercise may induce acute panic attacks or increase subjective anxiety in patients with panic disorder more than in other people. The effects of
    Thérèse Schunck et al.
    Journal of psychopharmacology (Oxford, England), 25(1), 52-59 (2010-05-26)
    Benzodiazepine effects on cholecystokinin tetrapeptide (CCK-4)-induced panic attack (PA) in humans are incompletely characterized, in particular on the neurofunctional level. This work explores the effects of lorazepam on brain activity and behavioral and physiological symptoms related to CCK-4-induced PA in
    Toyokazu Akimori et al.
    Medical molecular morphology, 44(1), 7-14 (2011-03-23)
    The function of brush cells is obscure, but recent cytochemical studies indicate that rat bile duct brush cells secrete NaHCO(3). The aim of this study was to determine the quantitative distribution of brush cells at 16 sites of the rat
    A C Dieler et al.
    Current pharmaceutical design, 14(33), 3492-3507 (2008-12-17)
    Pharmacological magnetic resonance imaging (phMRI) is a method to study effects of psychopharmacological agents on neural activation. Changes of the blood oxygen level dependent (BOLD), the basis of functional MRI (fMRI), are typically obtained at relatively high sampling frequencies. This
    Diana Koszycki et al.
    Peptides, 35(1), 9-13 (2012-03-15)
    Recent investigations suggest that genes that confer risk for panic disorder (PD) may moderate response to panicogenic agents in healthy volunteers. Given the potential role of the central cholecystokinin receptor (CCKBR) (CT) polymorphism alleles 26 and 27 in PD, the

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