所有图片(1)
About This Item
经验公式（希尔记法）:
C29H36N6O6S
CAS号:
分子量:
596.70
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
质量水平
方案
≥95% (HPLC)
表单
powder
分子量
59670 g/mol
技术
toxicology assay: suitable
溶解性
DMF: 20 mg/mL, clear, colorless to yellow
适用性
suitable for molecular biology
储存温度
−20°C
SMILES字符串
CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O
InChI
1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1
InChI key
RGYLYUZOGHTBRF-BIHRQFPBSA-N
基因信息
human ... CCK(885)
rat ... Cckbr(25706)
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Amino Acid Sequence
Trp-Met-Asp-Phe-NH2
一般描述
研究领域：神经科学
大脑中具有神经肽胆囊收缩素（CCK）的多个生物活性片段，它们在大脑中与CCK-A和 CCK-B受体相互作用。 在这些片段中，CCK-4在皮层和脑边缘系统中含量特别丰富。作为胆囊收缩素的生物活性形式，CCK-4是一种肽激素，通过结合肠道和脑中的CCK受体来调节食物摄入。
大脑中具有神经肽胆囊收缩素（CCK）的多个生物活性片段，它们在大脑中与CCK-A和 CCK-B受体相互作用。 在这些片段中，CCK-4在皮层和脑边缘系统中含量特别丰富。作为胆囊收缩素的生物活性形式，CCK-4是一种肽激素，通过结合肠道和脑中的CCK受体来调节食物摄入。
应用
胆囊收缩素片段 30-33 酰胺可用于灭活 CCK8 抗血清。 该产品也可用作吸收控制中的抗原，用于测试抗血清的特异性。胆囊收缩素片段 30-33 酰胺用于诱导小鼠中的抗焦虑和抗抑郁作用，并用于研究神经肽Y的作用。
生化/生理作用
胆囊收缩素片段 30-33 酰胺也称为 CCK-4 或 Trp-Met-Asp-Phe 酰胺是衍生自肽激素胆囊收缩素的肽片段。CCK-4 是引起人惊恐发作的惊恐试剂。化合物的这种性质可用于测试新抗焦虑药的科学研究。CCK-4 通过CCK-B受体选择性地起作用，其在情绪性行为调节中的作用得到广泛认可。 CCK 敲低小鼠研究表明其具有抗焦虑和抗抑郁作用。
包装
无底玻璃瓶。内含物装在插入的融合锥内。
制备说明
胆囊收缩素片段 30-33 酰胺溶于二甲基甲酰胺中，浓度为 20 mg/ml，得到澄清、无色至黄色的溶液。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
Thérèse Schunck et al.
Journal of psychopharmacology (Oxford, England), 25(1), 52-59 (2010-05-26)
Benzodiazepine effects on cholecystokinin tetrapeptide (CCK-4)-induced panic attack (PA) in humans are incompletely characterized, in particular on the neurofunctional level. This work explores the effects of lorazepam on brain activity and behavioral and physiological symptoms related to CCK-4-induced PA in
Andreas Ströhle et al.
Journal of psychiatric research, 43(12), 1013-1017 (2009-03-18)
Regular physical activity is anxiolytic in both healthy subjects and patients with panic disorder. In contrast, acute exercise may induce acute panic attacks or increase subjective anxiety in patients with panic disorder more than in other people. The effects of
A C Dieler et al.
Current pharmaceutical design, 14(33), 3492-3507 (2008-12-17)
Pharmacological magnetic resonance imaging (phMRI) is a method to study effects of psychopharmacological agents on neural activation. Changes of the blood oxygen level dependent (BOLD), the basis of functional MRI (fMRI), are typically obtained at relatively high sampling frequencies. This
Toyokazu Akimori et al.
Medical molecular morphology, 44(1), 7-14 (2011-03-23)
The function of brush cells is obscure, but recent cytochemical studies indicate that rat bile duct brush cells secrete NaHCO(3). The aim of this study was to determine the quantitative distribution of brush cells at 16 sites of the rat
H Fink et al.
Experimental brain research, 123(1-2), 77-83 (1998-12-03)
Cholecystokinin (CCK) is one of the first discovered gastrointestinal hormones and one of the most abundant neuropeptides in the brain. Two types of CCK receptors have been identified: (1) CCK-A receptors are mainly located in the periphery, but are also
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