T6402
抗τ (Tau) 兔抗
whole antiserum
别名:
Anti-DDPAC, Anti-FTDP-17, Anti-MAPTL, Anti-MSTD, Anti-MTBT1, Anti-MTBT2, Anti-PPND, Anti-PPP1R103, Anti-TAU, Anti-tau-40
产品名称
抗τ (Tau) 兔抗, whole antiserum
biological source
rabbit
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
contains
15 mM sodium azide
species reactivity
chicken, rat, mouse
technique(s)
western blot: 1:100 using rat or mouse brain tissue extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MAPT(4137)
Application
兔抗τ (Tau)抗体已用作免疫印迹分析中的一抗。
Biochem/physiol Actions
去除Tau (τ)可导致发育迟缓和学习障碍。它参与了阿尔茨海默病(AD)的发病机制。Tau蛋白有助于微管结构的组装和维护。
此抗体显示了广泛的物种反应性。抗-τ不会与MAP1、MAP2或微管蛋白发生反应。抗体与τ发生反应，即两种主要类别的热稳定的微管相关蛋白(MAP)之一。
编码tau蛋白的MAPT基因变异可导致额颞痴呆。Tau蛋白是许多激酶的底物。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
General description
Tau（τ），也称为MAPT（微管相关蛋白tau），由位于人染色体17q21.3上的基因编码。它在神经元中高表达，但在轴突中最显著。
Tau（τ），也称为微管相关蛋白tau（MAPT），由位于人染色体17q21.3上的基因编码。它在神经元中高表达，但在轴突中最显著。Tau是热稳定微管相关蛋白(MAP)，对应的分子量为55- 65 kDa。
Immunogen
τ 来自鸡胚脑微管的蛋白质。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Dendritic Tau in Alzheimer?s Disease
Ittner A, et al.
Neuron, 99(1), 13-27 (2018)
Yaqi Deng et al.
Genesis (New York, N.Y. : 2000), 52(4), 341-349 (2014-05-23)
Myelinogenesis is a complex process that involves substantial and dynamic changes in plasma membrane architecture and myelin interaction with axons. Highly ramified processes of oligodendrocytes in the central nervous system (CNS) make axonal contact and then extrapolate to wrap around
Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes
Miklossy J, et al.
Neurobiology of Aging, 27(2), 228-236 (2006)
Distinct neuroanatomical correlates of neuropsychiatric symptoms in the three main forms of genetic frontotemporal dementia in the GENFI cohort
Sellami L, et al.
Journal of Alzheimer'S Disease, 1-16 (2018)
Lieven Declercq et al.
Molecular imaging, 15 (2016-04-01)
Early clinical results of two tau tracers, [(18)F]T808 and [(18)F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acquire comparative preclinical data as well as to establish the
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