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Merck
CN
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文件

安全信息

T6271

Sigma-Aldrich

泰乐菌素 酒石酸酯

powder, suitable for cell culture, BioReagent

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MDL编号:
MFCD07783824
UNSPSC代码:
12352207
PubChem化学物质编号:
24900364
NACRES:
NA.76

产品线

BioReagent

质量水平

200

形式

powder

效能

≥800 units/mg tylosin

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

技术

cell culture | mammalian: suitable

颜色

off-white to yellow

溶解性

H2O: ≤50 mg/mL

抗生素抗菌谱

Gram-positive bacteria
mycoplasma

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(C)=C\[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC

InChI

1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1

InChI key

ICVKYYINQHWDLM-KBEWXLTPSA-N

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相关类别

一般描述

Chemical structure: macrolide

应用

Tylosin is a mcrolide antibiotic commonly used in veterinary medicine. It has been used to study protein synthesis at the 50S ribosome, implant site abscess prevention in cattle, disposition kinetics and Mycoplasma gallisepticumand Mycoplasma meleagridis infections. It is recommended for use in cell culture applications at 8 mg/L.

生化/生理作用

Mode of Action: Tylosin Tartrate inhibits bacterial protein synthesis by binding to the 50S (L27 protein) ribosome.

Antimicrobial Spectrum: This product acts against gram-positive bacteria and mycoplasma.

组分

泰乐菌素 A、B、C 和 D 酒石酸盐的混合物。

注意

Stock solutions should be filter sterilized and stored at 2-8°C. These solutions are stable at 37°C for 3 days.

其他说明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H317,H334

预防措施声明

P280 - P302 + P352

危险分类

Resp. Sens. 1 - Skin Sens. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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Mingfu Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(23), 14658-14663 (2002-11-06)
The macrolide antibiotic tylosin has been used extensively in veterinary medicine and exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin-synthesizing strains of the Gram-positive bacterium Streptomyces fradiae protect themselves from their own product by differential expression of four resistance determinants
N Gyémánt et al.
British journal of cancer, 103(2), 178-185 (2010-06-17)
The multidrug resistance (MDR) proteins are present in a majority of human tumours. Their activity is important to understand the chemotherapeutic failure. A search for MDR-reversing compounds was conducted among various Betti-base derivatives of tylosin. Here, we evaluate the in

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