所有图片(1)
别名:
N-甲苯磺酰基甘氨酰-L-脯氨酰-L-赖氨酸-4-硝基苯胺 乙酸盐
线性分子式:
C26H34N6O7S · C2H4O2
CAS号:
分子量:
634.70
EC 号:
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
质量水平
检测方案
≥98% (TLC)
形式
powder
溶解性
ethanol: 50 mg/mL, colorless to yellow
储存温度
−20°C
SMILES字符串
CC(O)=O.Cc1ccc(cc1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)Nc3ccc(cc3)[N+]([O-])=O
InChI
1S/C26H34N6O7S.C2H4O2/c1-18-7-13-21(14-8-18)40(38,39)28-17-24(33)31-16-4-6-23(31)26(35)30-22(5-2-3-15-27)25(34)29-19-9-11-20(12-10-19)32(36)37;1-2(3)4/h7-14,22-23,28H,2-6,15-17,27H2,1H3,(H,29,34)(H,30,35);1H3,(H,3,4)/t22-,23-;/m0./s1
InChI key
KPGSNEYSJPIZCW-SJEIDVEUSA-N
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应用
N-对甲苯磺酰基-甘氨酰-脯氨酰-赖氨酰-4-硝基苯胺乙酸盐已被用于：
- 作为aprE2、aprE5-41的酰胺水解活性检测的底物
- 作为丝氨酸蛋白酶和纤维蛋白原水解测定的底物
- 作为纤溶酶测定的底物
生化/生理作用
N-对甲苯磺酰基-甘氨酰-脯氨酰-赖氨酰-4-硝基苯胺乙酸盐是纤溶酶测定、丝氨酸蛋白酶活性和纤维蛋白原水解测定的显色底物。
底物
纤溶酶的发色底物。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Streptococcus pneumoniae choline-binding protein E interaction with plasminogen/plasmin stimulates migration across the extracellular matrix.
Attali C, et al.
Infection and Immunity, 76(2), 466-476 (2008)
Overexpression of aprE2, a Fibrinolytic Enzyme Gene from Bacillus subtilis CH3-5, in Escherichia coli and the Properties of AprE2.
Jeong SJ, et al.
Journal of microbiology and biotechnology, 24(7), 969-978 (2014)
Min Wang et al.
International journal of biological macromolecules, 146, 781-789 (2019-11-16)
The heterologous nature of SAK, a thrombolytic drug, elicits high titers of neutralizing antibodies, which limits its clinical use. Here, we aim to establish a SAK mutant with equivalent activity to the wild type but reduced antigenicity, which may allow
A bi-functional anti-thrombosis protein containing both direct-acting fibrin (ogen) olytic and plasminogen-activating activities
Yang H, et al.
PLoS ONE, 6(3), e17519-e17519 (2011)
Purification and characterization of a major fibrinolytic enzyme from Bacillus amyloliquefaciens MJ5-41 isolated from Meju
Jo HD, et al.
Journal of microbiology and biotechnology, 21(11), 1166-1173 (2011)
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