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T6137

三甲沙林

Name: 三甲沙林
Brand: SIGMA

≥98% (HPLC), powder, photochemical DNA crosslinker

别名:

2,5,9-三甲基呋[3,2-g]苯并吡喃-7-酮, 4,5′,8-三甲基补骨脂素, TMP, 三甲补骨脂内酯

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₂O₃

化学文摘社编号:

3902-71-4

分子量:

228.24

NACRES:

NA.77

PubChem Substance ID:

24900351

UNSPSC Code:

12352200

EC Number:

223-459-0

MDL number:

MFCD00005010

Beilstein/REAXYS Number:

221723

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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属性

产品名称

三甲沙林, ≥98% (HPLC), powder

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white

mp

229-231 °C (lit.)

solubility

chloroform: soluble 50 mg/mL, clear, colorless to faintly yellow

fluorescence

λ_ex 269 nm; λ_em 445 nm in methanol, λ_ex 321 nm; λ_em 445 nm (bound to DNA in Tris, pH 8.1)

originator

Valeant

storage temp.

−20°C

SMILES string

Cc1cc2cc3C(C)=CC(=O)Oc3c(C)c2o1

InChI

1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3

InChI key

FMHHVULEAZTJMA-UHFFFAOYSA-N

说明

Application

三甲沙林已被用于：

在蠕虫中诱导小缺失突变
与紫外A（UVA）
结合用于在DNA中诱导横向交联（ICL）
制备和光活化三甲基补骨脂素

三氧沙林已被用于 N2 蠕虫的诱变 ^4,5。

Biochem/physiol Actions

DNA 的光化学交联剂，可作为探针用于核酸结构和功能研究。

DNA 的光化学交联剂，可作为探针用于核酸结构和功能研究。三甲沙林也用于使 DNA 在云母表面交联。

三甲沙林是一种4,5′,8-三甲基化的补骨脂素类似物，属于呋喃并香豆素家族。它主要用于治疗银屑病。

Features and Benefits

这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

该化合物由Valeant开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

Preparation Note

三氧沙林可以50 mg/ml溶于氯仿并产生一种透明无色至淡黄色的溶液。

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pictograms

GHS08,GHS05,GHS07

signalword

Danger

hcodes

H312 + H332,H314,H341

pcodes

P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Dam. 1 - Muta. 2 - Skin Corr. 1B

存储类别

8A - Combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

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全球贸易项目编号

货号	GTIN
T6137-1G	04061837358388
T6137-500MG	04061837358395
T6137-100MG	04061837358371