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Merck
CN

T6069

Sigma-Aldrich

三乙烯硫代磷酰胺

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别名:
N,N′,N″-三乙撑硫代磷酰胺, 三(1-吖丙啶基)硫代磷酰, 三亚乙基硫代磷酰胺, 三胺硫磷, 噻替哌, 噻替派, 塞替派, 硫次膦基三氮丙啶
经验公式(希尔记法):
C6H12N3PS
CAS号:
分子量:
189.22
EC 号:
MDL编号:
UNSPSC代码:
51101500
PubChem化学物质编号:
NACRES:
NA.85

形式

solid

质量水平

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

white

抗生素抗菌谱

neoplastics

作用机制

DNA synthesis | interferes

储存温度

2-8°C

SMILES字符串

S=P(N1CC1)(N2CC2)N3CC3

InChI

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

InChI key

FOCVUCIESVLUNU-UHFFFAOYSA-N

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一般描述

化学结构:氮丙啶

应用

多官能烷基化剂

生化/生理作用

该不稳定的氮碳基团会与 DNA 烷基化,从而导致不可逆的 DNA 损伤。它们通过使 DNA 双螺旋链中的鸟嘌呤核苷交联来阻止肿瘤生长、直接攻击 DNA。DNA 链无法解开和分离,从而阻止了细胞分裂

分析说明

溶解度 - 完全溶于水、氯仿和乙醇(96%)

其他说明

保存于密闭容器内,置于干燥通风处。

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险声明

危险分类

Acute Tox. 2 Oral - Carc. 1B

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Ki Woong Sung et al.
Neuro-oncology, 15(3), 352-359 (2012-12-22)
We assessed the feasibility and effectiveness of reduced-dose craniospinal (CS) radiotherapy (RT) followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) in reducing late adverse effects without jeopardizing survival among children with high-risk medulloblastoma (MB). From October 2005
Samuel A Bobholz et al.
Tomography (Ann Arbor, Mich.), 6(2), 160-169 (2020-06-18)
Magnetic resonance (MR)-derived radiomic features have shown substantial predictive utility in modeling different prognostic factors of glioblastoma and other brain cancers. However, the biological relationship underpinning these predictive models has been largely unstudied, and the generalizability of these models had
B Kasenda et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 23(10), 2670-2675 (2012-04-05)
High-dose chemotherapy followed by autologous stem-cell transplantation (HCT-ASCT) is a promising approach in eligible patients with primary central nervous system lymphoma (PCNSL). We report long-term data of patients who were treated according to HCT-ASCT containing protocols. We analyzed survival and
Joerg C Henes et al.
Rheumatology (Oxford, England), 53(5), 919-922 (2014-01-25)
The aim of this study was to find a new and less cardiotoxic conditioning regimen for high-dose chemotherapy and autologous stem cell transplantation (aSCT) in patients with severe SSc and pre-existing cardiac involvement. Six patients with cardiac involvement were treated
J Sanz et al.
Bone marrow transplantation, 47(10), 1287-1293 (2012-02-14)
Attempts to optimize outcomes in cord blood transplantation (CBT) by using new conditioning regimens and standardization of cord blood unit selection are warranted. In all, 88 patients (18 children and 70 adults) with hematological malignancy from nine Spanish institutions underwent

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