推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 46 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
microarray: suitable
western blot: 1-2 μg/mL using cell lysates of rat fibroblast Rat-1, mouse fibroblast NIH3T3, and human A431 cells, and rat brain extract (S1 cytosolic fraction)
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TSG101(7251)
mouse ... Tsg101(22088)
rat ... Tsg101(292925)
一般描述
Tumor susceptibility gene 101 protein (TSG101) is mapped to human chromosome 11p15.1. TSG101 has ubiquitin E2 variant domain.
免疫原
synthetic peptide corresponding amino acids 2-20 located at the N-terminus of human TSG101, conjugated to KLH. This sequence is identical in rat and mouse TSG101.
生化/生理作用
Tumor susceptibility gene 101 protein (TSG101) is a component of endosomal sorting complex required for transport (ESCRT) machinery. TSG101 interacts with arrestin domain-containing protein 1 and mediates its budding through plasma membrane. It binds to ubiquitinylated proteins and conveys them for degradation by lysosomes. TSG101 is also essential for the budding human immunodeficiency virus (HIV) infected cells. TSG101 deficiency is associated with genome instability and is considered as a risk factor for tumor initiation.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
推荐
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency
Xie W, et al.
Proceedings of the National Academy of Sciences of the USA, 95(4), 1595-1600 (1998)
Ubiquitin recognition by the human TSG101 protein
Sundquist WI, et al.
Molecular Cell, 13(6), 783-789 (2004)
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
Garrus JE, et al.
Cell, 107(1), 55-65 (2001)
Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.
Nabhan JF, et al.
Proceedings of the National Academy of Sciences of the USA, 109(11), 4146-4151 (2012)
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