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Merck
CN

T5625

(±)-α-硫辛酸

synthetic, ≥99% (titration), powder

别名:

(±)-1,2-二硫戊环基-3-戊酸, 6,8-二巯基辛酸, DL-α-硫辛酸, DL-6,8-硫辛酸, Lip(S2)

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关于此项目

经验公式（希尔记法）:
C8H14O2S2
化学文摘社编号:
1077-28-7
分子量:
206.33
UNSPSC Code:
12352106
NACRES:
NA.77
PubChem Substance ID:
57654679
EC Number:
214-071-2
Beilstein/REAXYS Number:
81853
MDL number:
MFCD00005474
Assay:
≥99% (titration)
Form:
powder
Quality level:
200

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产品名称

(±)-α-硫辛酸, synthetic, ≥99% (titration), powder

InChI key

AGBQKNBQESQNJD-UHFFFAOYSA-N

InChI

1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)

SMILES string

OC(=O)CCCCC1CCSS1

biological source

synthetic

description

Oxidized form

assay

≥99% (titration)

form

powder

solubility

ethanol: soluble 50 mg/mL

Quality Level

200

Gene Information

human ... ACHE(43), BCHE(590)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)

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Application

α-LA可以恢复高脂肪喂养的糖尿病大鼠的内皮活动，并减轻氧化应激4。它还用于分析星形胶质细胞中的ROS 产生5。

Biochem/physiol Actions

维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物）活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后，该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子（尤其是 NF-κB）的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。
维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶）活性所需的抗氧化剂和辅酶。

Preparation Note

（±）-α-硫辛酸（α-LA）以 50mg/ml的浓度溶于乙醇

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000472157
0000472157
0000507523
0000507542
0000507541

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Massimo Dal Monte et al.
Diagnostics (Basel, Switzerland), 10(3) (2020-03-07)
Melatoninergic agents are known to reduce intraocular pressure (IOP). The present study was performed to evaluate the effect of nanomicellar formulations of melatoninergic agents on IOP in the rat. Tonometry was used to measure IOP in eyes instilled with melatonin
Fatma M Ghoneim et al.
Biology, 9(9) (2020-08-23)
Sodium valproate (VPA) is an antiepileptic drug (AED) licensed for epilepsy and used during pregnancy in various indications. Alpha-lipoic acid (ALA) is a natural compound inducing endogenous antioxidant production. Our study aimed to investigate the effect of prenatal administration of
Daniely V S Costa et al.
Pharmaceuticals (Basel, Switzerland), 13(11) (2020-11-07)
Irinotecan, an anticancer drug, induces diarrhea and intestinal inflammation, resulting in an increase in the cost of care and in treatment delays. In this study, we investigated whether alpha-lipoic acid (α-LA) could improve irinotecan-mediated intestinal inflammation, diarrhea and dysmotility. Intestinal
Reda Hassan Elbakary et al.
Journal of microscopy and ultrastructure, 8(2), 42-50 (2020-08-09)
Polychlorinated biphenyl (PCB) is considered one of the environmental pollutants. It is used as hydraulic coils in vacuum pumps, pesticides transformers, heat-exchange systems, capacitors and as additives in adhesive inks, paints, plastics, copying paper and sealants. Alpha lipoic acid (ALA)
Michela Rosini et al.
European journal of medicinal chemistry, 46(11), 5435-5442 (2011-09-20)
Lipoic acid (LA) is a natural antioxidant. Its structure was previously combined with that of the acetylcholinesterase inhibitor tacrine to give lipocrine (1), a lead compound multitargeted against Alzheimer's disease (AD). Herein, we further explore LA as a privileged structure
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