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Merck
CN

T5442

Sigma-Aldrich

Anti-ADAM-17 (TACE), C-Terminal antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

Anti-TACE, Anti-TNF-α Converting Enzyme

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About This Item

MDL编号:
UNSPSC代码:
12352203

生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen 80-130 kDa (wide band representing mature protein, precursor and glycosylated TACE)

种属反应性

mouse, rat, human

浓度

~0.5 mg/mL

技术

microarray: suitable
western blot: 0.25-1 μg/mL using HeLa or Jurkat cell lysates

UniProt登记号

运输

dry ice

储存温度

−20°C

基因信息

human ... ADAM17(6868)
mouse ... Adam17(11491)
rat ... Adam17(57027)

免疫原

synthetic peptide corresponding to the C-terminal amino acids 807-823 of human TNF-α converting enzyme (TACE). This peptide differs from mouse and rat by only one amino acid.

外形

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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访问文档库

Anna A Pimenova et al.
PloS one, 9(1), e87014-e87014 (2014-01-28)
Proteolytic processing of the amyloid precursor protein (APP) by the β- and γ-secretases releases the amyloid-β peptide (Aβ), which deposits in senile plaques and contributes to the etiology of Alzheimer's disease (AD). The α-secretase cleaves APP in the Aβ peptide
C Y Chua et al.
Oncogene, 35(6), 738-747 (2015-04-22)
Insulin-like growth factor binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that has both extracellular and intracellular functions. Despite a clear causal role in cancer development, the tumor-promoting mechanisms of IGFBP2 are poorly understood. The contributions of intracellular IGFBP2

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