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产品名称
Transforming Growth Factor-β3 human, TGF-β3, recombinant, expressed in baculovirus infected Sf21 cells, powder, suitable for cell culture
生物来源
human
质量水平
重组
expressed in baculovirus infected Sf21 cells
方案
≥97% (SDS-PAGE)
表单
powder
效能
0.01-0.09 ng/mL ED50/EC50
质量
endotoxin tested
分子量
predicted mol wt ~25 kDa
包装
pkg of 2 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
<0.01 EU/μg
UniProt登记号
储存温度
−20°C
基因信息
human ... TGFB3(7043)
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一般描述
The TGFβ3 (transforming Growth Factor-β3) gene is mapped to human chromosome 14q24.3.
应用
Transforming Growth Factor-β3 human has been used to study the role of TGF-β3 in healing tendon-to-bone insertion and in chondrogenic differentiation.
生化/生理作用
TGF-β (transforming growth factor-β3) isoforms are significantly involved in inducing inflammatory responses. It is associated with vascular diseases, wound healing and ameliorating effect in venous leg ulcer. TGF-β3 has an antagonistic effect on TGF-β1 and reduces the degree of collagen type I deposition and fibroblast differentiation. As a result TGF-β3 might lead to ulcer chronicity due to hindered myofibroblasts formation. TGF-β is a key player in tumor formation and progression. Increased TGF-β3 expression is observed in cancer and adipose tissue fibrosis. TGF-β3 is crucial in tissue regeneration and scarless tissue repair.
TGF-β3 is less prevalent in natural expression than either TGF-β1 or TGF-β2, but it is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord, in a variety of mesenchymal cells of human and rodent origin, and in several human carcinoma cells.
外形
Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.
分析说明
The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway
Alves MJ, et al.
BMC Cancer, 17: 190 (2017)
Differential expression of TGF isoforms in breast cancer highlights different roles during breast cancer progression.
Hachim MY, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 40(1) (2018)
Roberts, A., and Sporn, M. et al.
Peptide Growth Factors and their Receptors I, 419-472 (1991)
The role of transforming growth factor β isoforms in tendon-to-bone healing.
Kim HM, et al.
Connective tissue research, ;52(2), 87-98 (2011)
Chondrogenic Differentiation of Menstrual Blood-Derived Stem Cells on Nanofibrous Scaffolds
Kazemnejad S, et al.
Methods in Molecular Biology, 149-169 (2013)
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