T5425
Transforming Growth Factor-β3 human
≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, powder, suitable for cell culture
别名:
hTGF-β3, TGF-β3
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关于此项目
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
Assay:
≥97% (SDS-PAGE)
Form:
powder
Mol wt:
predicted mol wt ~25 kDa
Impurities:
<0.01 EU/μg
产品名称
Transforming Growth Factor-β3 human, TGF-β3, recombinant, expressed in baculovirus infected Sf21 cells, powder, suitable for cell culture
biological source
human
recombinant
expressed in baculovirus infected Sf21 cells
assay
≥97% (SDS-PAGE)
form
powder
potency
0.01-0.09 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
predicted mol wt ~25 kDa
packaging
pkg of 2 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
<0.01 EU/μg
UniProt accession no.
storage temp.
−20°C
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General description
The TGFβ3 (transforming Growth Factor-β3) gene is mapped to human chromosome 14q24.3.
Application
Transforming Growth Factor-β3 human has been used to study the role of TGF-β3 in healing tendon-to-bone insertion and in chondrogenic differentiation.
Biochem/physiol Actions
TGF-β (transforming growth factor-β3) isoforms are significantly involved in inducing inflammatory responses. It is associated with vascular diseases, wound healing and ameliorating effect in venous leg ulcer. TGF-β3 has an antagonistic effect on TGF-β1 and reduces the degree of collagen type I deposition and fibroblast differentiation. As a result TGF-β3 might lead to ulcer chronicity due to hindered myofibroblasts formation. TGF-β is a key player in tumor formation and progression. Increased TGF-β3 expression is observed in cancer and adipose tissue fibrosis. TGF-β3 is crucial in tissue regeneration and scarless tissue repair.
TGF-β3 is less prevalent in natural expression than either TGF-β1 or TGF-β2, but it is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord, in a variety of mesenchymal cells of human and rodent origin, and in several human carcinoma cells.
Physical form
Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.
Analysis Note
The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Differential expression of TGF isoforms in breast cancer highlights different roles during breast cancer progression.
Hachim MY, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 40(1) (2018)
Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway
Alves MJ, et al.
BMC Cancer, 17: 190 (2017)
The role of transforming growth factor β isoforms in tendon-to-bone healing.
Kim HM, et al.
Connective tissue research, ;52(2), 87-98 (2011)
Chondrogenic Differentiation of Menstrual Blood-Derived Stem Cells on Nanofibrous Scaffolds
Kazemnejad S, et al.
Methods in Molecular Biology, 149-169 (2013)
Tsang, M., et al.
Proc. 7th Intl. Lymphokine Workshop, 9, 607-607 (1990)
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