产品名称
抗-β微管蛋白同种型 III 抗体，小鼠单克隆 小鼠抗, clone SDL.3D10, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
SDL.3D10, monoclonal
form
buffered aqueous solution
species reactivity
mouse, rat, human, boar, bovine
packaging
antibody small pack of 25 μL
concentration
~2 mg/mL
technique(s)
dot blot: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.1-0.2 μg/mL using rat brain extract
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TUBB3(10381)
mouse ... Tubb3(22152)
rat ... Tubb3(246118)
Application
Ⅲ型β-微管蛋白单克隆抗体（1∶500稀释）可用作神经元免疫细胞化学分析的一抗。它还可用于通过斑点印迹、ELISA和免疫组化等数种免疫化学测定法定位III型β-微管蛋白。
小鼠抗Ⅲ型β-微管蛋白单克隆抗体还可用于免疫标记和流式细胞术。
Biochem/physiol Actions
III类微管蛋白β 3（TUB3）调节神经形成并参与轴突引导和维持。该基因的突变与连合轴突（CA）发育不全、3型先天性眼外肌纤维化（CFEOM3）和脑回异常有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
III类微管蛋白β 3（TUBB3）编码微管蛋白β-3，该蛋白主要在神经元中表达。该基因位于人类染色体16q24.3。
微管蛋白是微管的主要组成部分，该蛋白由两种相似的α多肽和β多肽组成，每种多肽的分子量约为50 kD。它具有多种细胞功能，如有丝分裂、减数分裂、某些形式的细胞器运动、胞内转运、鞭毛运动和细胞骨架功能。Ⅲ型β-微管蛋白单克隆抗体可用于微阵列和蛋白印迹。它还可用于免疫印迹法。小鼠抗Ⅲ型β-微管蛋白抗体与牛、大鼠、小鼠、公猪和人β-微管蛋白（III型）上存在的表位特异性反应，但不与鸡脑提取物或鸡成纤维细胞系中存在的微管蛋白反应。
Immunogen
该肽对应于人 β-微管蛋白亚型III的羧基末端序列，与BSA偶联。
Other Notes
Physical form
溶于含有15 mM叠氮化钠的0.01 M磷酸盐缓冲液中。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Two unique TUBB3 mutations cause both CFEOM3 and malformations of cortical development
Whitman MC, et al.
American Journal of Medical Genetics. Part A, 170(2), 297-305 (2016)
Childhood-onset schizophrenia case with 2.2 Mb deletion at chromosome 3p12. 2-p12. 1 and two large chromosomal abnormalities at 16q22. 3-q24. 3 and Xq23-q28
Rudd D, et al.
Clinical case reports, 3(4), 201-207 (2015)
J Pĕknicová et al.
Biology of reproduction, 65(3), 672-679 (2001-08-22)
The exposure of tubulin epitopes was studied in ejaculated boar spermatozoa using a panel of four monoclonal antibodies specific to the N-terminal or C-terminal structural domains of tubulin and three monoclonal antibodies against class III beta-tubulin. The specificity of the
Increased microtubule assembly in bovine brain tubulin lacking the type III isotype of beta-tubulin.
A Banerjee et al.
The Journal of biological chemistry, 265(3), 1794-1799 (1990-01-25)
Tubulin, the major constituent protein of microtubules, is a heterodimer of alpha and beta subunits. Both alpha and beta exist in multiple isotypic forms. It is not clear if different isotypes perform different functions. In order to approach this question
Human TUBB3 Mutations Disrupt Netrin Attractive Signaling
Huang H, et al.
Neuroscience, 374, 155-171 (2018)
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