T5050
Transforming Growth Factor-β1 来源于猪血小板
≥97% (SDS-PAGE), recombinant, powder, suitable for cell culture
别名:
TGF-β1
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关于此项目
Biological source:
Porcine (Platelets)
Assay:
≥97% (SDS-PAGE)
Form:
powder
Mol wt:
protein 25 kDa
Impurities:
≤1 EU/μg
产品名称
Transforming Growth Factor-β1 来源于猪血小板, TGF-β1, powder, suitable for cell culture
biological source
Porcine (Platelets)
assay
≥97% (SDS-PAGE)
form
powder
potency
0.01-0.1 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
protein 25 kDa
packaging
pkg of 1 μg, pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
General description
The TGFB (transforming growth factor-β) gene is mapped to pig (Sus scrofa) chromosome between 6q11-q21. In mammals, TGFβ is present in three isoforms (TGFβ1, TGFβ2 and TGFβ3), of which TGFβ1 is predominant.
Application
Transforming Growth Factor-β1 from porcine platelets has been used in chondrogenic differentiation. It has also been used in immobilization process.
Biochem/physiol Actions
TGF-β1 is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2.
Transforming growth factor-β1 (TGF-β) is a multifunctional polypeptide growth factor. TGF-β mediates cell proliferation, differentiation and migration. Important cellular functions such as inflammation, extracellular matrix synthesis, epithelial restoration and developmental processes are also controlled by TGF-β. TGF-β controls the regulation of enamel mineralization in porcine. TGF-β is associated with the development of idiopathic pulmonary fibrosis (a chronic lung disease). TGF-β promotes epithelial-mesenchymal transition (EMT) and contributes to proliferation and metastasis of cancer. The TGF-β induced EMT is observed in kidney fibrosis. TGF-β is stimulates regeneration of intestinal tissue.
Physical form
Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.05 mg bovine serum albumin per μg cytokine.
Analysis Note
The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
TGF-β1 autocrine signalling and enamel matrix components
Kinoshita SK, et al.
Scientific Reports (2016)
Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β
Ding Q, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 312(6), L926-L935 (2017)
Isolation, culture and chondrogenic differentiation of canine
adipose tissue- and bone marrow-derived mesenchymal stem
cells?a comparative study
adipose tissue- and bone marrow-derived mesenchymal stem
cells?a comparative study
Reich CM, et al.
Veterinary Research Communications, 36, 139-148 (2012)
TGF-β1 immobilized tri-co-polymer for articular cartilage tissue engineering.
Chou CH, et al.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 77(2), 338-348 (2006)
Effect of Conceptus on Transforming Growth Factor (TGF) β1 mRNA Expression and Protein Concentration in the Porcine Endometrium?In Vivo and In Vitro Studies
Blitek A, et al.
Journal of Reproduction and Development, 59(6), 512-519 (2013)
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