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Merck
CN
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文件

安全信息

T4887

Sigma-Aldrich

T-2毒素

from Fusarium sp., powder, ≥98% (HPLC)

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别名:
12,13-环氧单端孢霉-9-烯-3,4,8,15-四醇-4,15-二醋酸酯-8-异戊酸酯, 4β,15-二乙酰氧基-3α-羟基-8α-(3-甲基丁酰氧基)-12,13-环氧单端孢霉-9-烯
经验公式（希尔记法）:
C24H34O9
CAS号:
21259-20-1
分子量:
466.52
Beilstein:
3575695
EC 号:
244-297-7
MDL编号:
MFCD00871255
UNSPSC代码:
12352200
PubChem化学物质编号:
24900234
NACRES:
NA.77

生物来源

Fusarium sp.

质量水平

200

检测方案

≥98% (HPLC)

形式

powder

存货情况

not available in USA, Japan

颜色

white

溶解性

chloroform: soluble 9.80-10.20 mg/mL, clear, colorless to faintly yellow
DMSO: freely soluble
petroleum ether: slightly soluble

储存温度

−20°C

SMILES字符串

[H][C@]12O[C@]3([H])[C@H](O)[C@@H](OC(C)=O)[C@](C)([C@@]1(COC(C)=O)C[C@H](OC(=O)CC(C)C)C(C)=C2)[C@]34CO4

InChI

1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24-/m0/s1

InChI key

BXFOFFBJRFZBQZ-QYWOHJEZSA-N

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应用

T-2 toxin can cause degenerative lesions in articular cartilage of rats8. Furthermore, immunotoxicity studies have reported that T-2 toxin can cause cell death in human lymphoid T cells and also induces cell membrane damage in B cells9.

生化/生理作用

The trichothecenes, such as T2 Toxin, are mycotoxins produced by fungi of the genus Fusarium. They are commonly present in foods and feed of cereal origin. T-2 toxin induces DNA damage and cell death on prolonged administration. These effects can be partially blocked by antioxidants, such as glutathione, coenzyme Q10, or α-tocopherol. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain.

质量

色谱纯化产品

制备说明

T-2 Toxin is soluble in chloroform at 9.80 - 10.20 mg/ml and yields a clear, colorless to faint yellow solution. Furthermore, the product is freely soluble in DMSO and slightly soluble in petroleum ether.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Skin Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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F Atroshi et al.
Molecular aspects of medicine, 18 Suppl, S255-S258 (1997-01-01)
Active oxygen species are reported to cause organ damage. This study was therefore designed to determine whether oxidative stress contributed to the initiation or progression of hepatic DNA damage produced by T-2 toxin. The aim of the study was also
J Shinozuka et al.
Toxicologic pathology, 26(5), 674-681 (1998-10-28)
We examined T-2 toxin-induced lesions in the bone marrow and splenic red pulp as many as 48 hr after oral inoculation with 10 mg/kg body weight of T-2 toxin in female ICR:CD-1 mice. Histopathologically, the bone marrow and splenic red
Z Islam et al.
Bioscience, biotechnology, and biochemistry, 62(8), 1492-1497 (1998-10-03)
Recently we found that a single administration of T-2 toxin (T-2), a trichothecene mycotoxin, into mice induced DNA fragmentation, a biochemical hallmark of apoptosis, in the thymus. In this study, we investigated the effective chemical structure(s) of T-2-derived metabolites capable
Paweł Wojtacha et al.
Toxins, 13(4) (2021-05-01)
Plant materials used in the production of pig feed are frequently contaminated with mycotoxins. T-2 toxin is a secondary metabolite of selected Fusarium species, and it can exert a harmful influence on living organisms. Most mycotoxins enter the body via
A Thuvander et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(6), 639-648 (1999-09-09)
The trichothecenes are mycotoxins produced by fungi of the genus Fusarium, which are commonly present in foods and feed of cereal origin. Owing to the lack of sufficient toxicological data for most of the trichothecenes, in vitro studies may contribute
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