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Merck
CN

T4687

Sigma-Aldrich

硫柳汞钠

meets USP testing specifications

别名:

Mercury-([o-carboxyphenyl]thio)ethyl 钠盐, 乙基噻吩酸 钠盐, 乙汞硫柳酸钠, 乙汞硫水杨酸 钠盐

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About This Item

线性分子式:
2-(C2H5HgS)C6H4CO2Na
CAS号:
分子量:
404.81
Beilstein:
8169555
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:

生物来源

synthetic (Organic)

Agency

USP/NF
meets USP testing specifications

表单

powder

mp

234-237 °C (dec.) (lit.)

痕量阳离子

Hg: ≤0.70% (ions)

作用机制

enzyme | inhibits

SMILES字符串

[Na+].CC[Hg]Sc1ccccc1C([O-])=O

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

InChI key

RTKIYNMVFMVABJ-UHFFFAOYSA-L

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生化/生理作用

硫柳汞是一种巯基(硫醇)氧化剂,能抑制多种巯基依赖性酶和蛋白质,如PI3激酶依赖性蛋氨酸合成酶、谷氨酸转运受体和Na++K+依赖性ATP酶。

其他说明

As part of the corporation global plan to support the Minamata Convention eliminating mercury-containing compounds, as of January 2021 customers will be required to provide an End-Use Declaration. Sales of thimerosal will be restricted for approved applications only.
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

免责声明

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

警示用语:

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

靶器官

Kidney

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

危险化学品
非剧毒-急性毒性1

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Pan-Chyr Yang et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 111(6), 333-339 (2012-07-04)
This study evaluated the immune response elicited by two formulations of an AS03(A)-adjuvanted H5N1 A/Indonesia/05/2005 prepandemic influenza vaccine, developed using manufacturing processes with or without thiomersal. In addition, it also evaluated compliance to the Centre for Biologics Evaluation and Research
Dorota Mrozek-Budzyn et al.
Neurotoxicology and teratology, 34(6), 592-597 (2012-10-17)
Despite the common use of Thimerosal as a preservative in childhood vaccines since the 1930s, there are not many studies on ethylmercury toxicokinetics and toxicodynamics in infants. The knowledge of ethylmercury's potential adverse effects is derived mostly from parallel methylmercury
L K Ball et al.
Pediatrics, 107(5), 1147-1154 (2001-05-23)
On July 7, 1999, the American Academy of Pediatrics and the US Public Health Service issued a joint statement calling for removal of thimerosal, a mercury-containing preservative, from vaccines. This action was prompted in part by a risk assessment from
José G Dórea
Clinica chimica acta; international journal of clinical chemistry, 411(21-22), 1580-1586 (2010-07-20)
To compare epidemiological studies dealing with neurological issues (compatible with Hg toxicity) linked to exposing newborns and infants to intramuscular doses of preservative-Hg resulting from vaccination with thimerosal-containing vaccines (TCV). Major databases were searched for studies that addressed neurodevelopment outcomes
José G Dórea
Neurochemical research, 36(6), 927-938 (2011-02-26)
There is a need to interpret neurotoxic studies to help deal with uncertainties surrounding pregnant mothers, newborns and young children who must receive repeated doses of Thimerosal-containing vaccines (TCVs). This review integrates information derived from emerging experimental studies (in vitro

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