所有图片(3)
About This Item
经验公式（希尔记法）:
C9H15N5O3 · 2HCl
CAS号:
分子量:
314.17
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
产品名称
（6R）-5,6,7,8-四氢生物蝶呤 二盐酸盐,
质量水平
溶解性
water, oxygen free: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2=C(N1)C(=O)NC(N)=N2
InChI
1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
InChI key
RKSUYBCOVNCALL-NTVURLEBSA-N
基因信息
human ... PAH(5053)
一般描述
四氢生物蝶呤是苯丙氨酸羟化酶、酪氨酸羟化酶、色氨酸羟化酶、一氧化氮合酶和烷基甘油单加氧酶的天然辅助因子。
应用
(6R)-BH4作为缓冲液组成部分，用于测定小鼠脑组织中酪氨酸羟化酶的活性。(6R)-BH4还被视为通过荧光- α葡糖苷酶测定法从LOPAC库中确定为激活剂化合物。
生化/生理作用
缺乏四氢生物蝶呤可能导致高苯丙氨酸血症。诸如帕金森氏症′、自闭症、抑郁症和阿尔茨海默症′等疾病都表明脑脊液中四氢生物蝶呤的浓度很低。这种辅酶参与多巴胺(DA)的合成。
特点和优势
制备说明
（6R）-5，6，7，8-四氢生物蝶呤二盐酸盐（（6R）-BH4）可溶于19.60 - 20.40毫克/毫升的无氧水中，并产生一种清澈至微混浊、无色至淡黄色的溶液。
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Katja Schmitz et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18(3), 1862-1879 (2021-04-13)
Depletion of the enzyme cofactor, tetrahydrobiopterin (BH4), in T-cells was shown to prevent their proliferation upon receptor stimulation in models of allergic inflammation in mice, suggesting that BH4 drives autoimmunity. Hence, the clinically available BH4 drug (sapropterin) might increase the
E R Werner et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 203(1), 1-12 (1993-05-01)
Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yields the first intermediate, 7,8-dihydroneopterin triphosphate. This compound is then converted by subsequent enzymes, 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase, to tetrahydrobiopterin, the biologically
José Carlos Rivera et al.
Journal of neuroinflammation, 14(1), 181-181 (2017-09-07)
Tetrahydrobiopterin (BH4) is an essential cofactor in multiple metabolic processes and plays an essential role in maintaining the inflammatory and neurovascular homeostasis. In this study, we have investigated the deleterious effects of BH4 deficiency on retinal vasculature during development. hph-1
Rebecca Ebenhoch et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(50), 31838-31849 (2020-11-25)
Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) catalyzes the conversion of GTP to dihydroneopterin triphosphate (H2NTP), the initiating step in the biosynthesis of tetrahydrobiopterin (BH4). Besides other roles, BH4 functions as cofactor in neurotransmitter biosynthesis. The BH4 biosynthetic pathway and GCH1
Pteridines
Colette DS, et al.
reference module in biomedical sciences (2018)
商品
血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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