生物来源
human
质量水平
重组
expressed in baculovirus infected Sf9 cells
产品线
PRECISIO® Kinase
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
比活
19-25 nmol/min·mg
分子量
~66 kDa
技术
activity assay: suitable
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... NTRK1(4914)
应用
TRKA (440-end), active, GST tagged human was used to study functional NGF signal transduction.
生化/生理作用
TRKA (440-end), active, GST tagged human is a 140 kD membrane-spanning protein tyrosine kinase that belongs to proto-oncogene family. TRKA facilitates the regulation of cell differentiation and survival via activating SHC1 and FRS2 which in turn activates a GRB2-Ras-MAPK cascade. It also plays a pivotal role in controlling NF-κ-B activation as well as transcription of genes involved in cell survival via PLCG1.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
F Boissière et al.
Molecular and chemical neuropathology, 28(1-3), 219-223 (1996-05-01)
The most consistent neuropathological finding in Alzheimer disease (AD) is the loss of cholinergic neurons of the nucleus basalis of Meynert (NbM). Using immunohistochemistry, we have previously shown that cholinergic neurons located in the ventral striatum were affected, whereas those
F Iannone et al.
Rheumatology (Oxford, England), 41(12), 1413-1418 (2002-12-07)
We aimed to investigate the expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) on chondrocytes from human healthy and osteoarthritic cartilage. We recruited 12 patients with osteoarthritis (OA) undergoing surgical knee replacement. Articular cartilage was
Ilaria Caon et al.
Cancers, 13(5) (2021-04-04)
Interaction between cancer cells and their microenvironment is central in defining the fate of cancer development. Tumour cells secrete signals (cytokines, chemokines, growth factors) that modify the surrounding area, while the niche supplies structures and activities necessary for tumour maintenance
R M Stephens et al.
Neuron, 12(3), 691-705 (1994-03-01)
In response to NGF, the Trk receptor tyrosine kinase forms a complex with SHC, a protein that couples receptor tyrosine kinases to p21ras. Complex formation between Trk and SHC, SHC tyrosine phosphorylation, and association of SHC with Grb2 were mediated
D R Kaplan et al.
Science (New York, N.Y.), 252(5005), 554-558 (1991-04-26)
The trk proto-oncogene encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase (p140prototrk) that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of p140prototrk in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium
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