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Merck
CN

T4193

Sigma-Aldrich

TNP-ATP hydrate

≥90% (HPLC), powder

别名:

2′,3′-O-(2,4,6-Trinitrophenyl) adenosine 5′-triphosphate monolithium trisodium salt

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About This Item

经验公式(希尔记法):
C16H13N8O19P3LiNa3 · xH2O
分子量:
790.15 (anhydrous basis)
UNSPSC代码:
12352200

方案

≥90% (HPLC)

表单

powder

颜色

red to orange

溶解性

H2O: <5 mg/mL
PBS: soluble

运输

dry ice

储存温度

−70°C

SMILES字符串

[Li+].O.[Na+].[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)CP([O-])(=O)CP([O-])([O-])=O)[C@H]4OC5(O[C@@H]34)C(CC(CC5[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O

应用

TNP-ATP has been used to inhibit P2X4 in rat microglial cells2. It has also been used as a P2X receptor antagonist in mice3.

生化/生理作用

TNP-ATP hydrate is a purinoceptor P2X2/3 antagonist.

制备说明

TNP-ATP hydrate is soluble in water at a concentration that is less than or equal to 5 mg/ml. It is also soluble in PBS3.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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M F Jarvis et al.
British journal of pharmacology, 132(1), 259-269 (2001-01-13)
1. Exogenous ATP produces acute and localized pain in humans, and P2X receptor agonists elicit acute nociceptive behaviours in rodents following intradermal administration to the hindpaw. The predominant localization of P2X(3) mRNA in sensory neurones has led to the hypothesis
Koji Atarashi et al.
Nature, 455(7214), 808-812 (2008-08-22)
Interleukin (IL)-17-producing CD4(+) T lymphocytes (T(H)17 cells) constitute a subset of T-helper cells involved in host defence and several immune disorders. An intriguing feature of T(H)17 cells is their selective and constitutive presence in the intestinal lamina propria. Here we
Fan Li et al.
BMC neuroscience, 12, 111-111 (2011-11-08)
Activation of amoeboid microglial cells (AMC) and its related inflammatory response have been linked to the periventricular white matter damage after hypoxia in neonatal brain. Hypoxia increases free ATP in the brain and then induces various effects through ATP receptors.

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