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方案
≥90% (HPLC)
表单
powder
颜色
red to orange
溶解性
H2O: <5 mg/mL
PBS: soluble
运输
dry ice
储存温度
−70°C
SMILES字符串
[Li+].O.[Na+].[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)CP([O-])(=O)CP([O-])([O-])=O)[C@H]4OC5(O[C@@H]34)C(CC(CC5[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O
应用
TNP-ATP has been used to inhibit P2X4 in rat microglial cells2. It has also been used as a P2X receptor antagonist in mice3.
生化/生理作用
TNP-ATP hydrate is a purinoceptor P2X2/3 antagonist.
制备说明
TNP-ATP hydrate is soluble in water at a concentration that is less than or equal to 5 mg/ml. It is also soluble in PBS3.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
M F Jarvis et al.
British journal of pharmacology, 132(1), 259-269 (2001-01-13)
1. Exogenous ATP produces acute and localized pain in humans, and P2X receptor agonists elicit acute nociceptive behaviours in rodents following intradermal administration to the hindpaw. The predominant localization of P2X(3) mRNA in sensory neurones has led to the hypothesis
Koji Atarashi et al.
Nature, 455(7214), 808-812 (2008-08-22)
Interleukin (IL)-17-producing CD4(+) T lymphocytes (T(H)17 cells) constitute a subset of T-helper cells involved in host defence and several immune disorders. An intriguing feature of T(H)17 cells is their selective and constitutive presence in the intestinal lamina propria. Here we
Fan Li et al.
BMC neuroscience, 12, 111-111 (2011-11-08)
Activation of amoeboid microglial cells (AMC) and its related inflammatory response have been linked to the periventricular white matter damage after hypoxia in neonatal brain. Hypoxia increases free ATP in the brain and then induces various effects through ATP receptors.
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