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Merck
CN

T3955

Sigma-Aldrich

TNP

≥95% (HPLC)

别名:

N2-(间三氟苄基),N6-(对硝基苄基)嘌呤; N6-[(4-硝基苯基)甲基] -N2-[[3-(三氟甲基)苯基]甲基] -9H-嘌呤-2,6-二胺;N6-[(4-硝基苯基)甲基] -N2-[[3-(三氟甲基)苯基]甲基] -1H-嘌呤-2,6-二胺

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About This Item

经验公式(希尔记法):
C20H16F3N7O2
分子量:
443.38
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥95% (HPLC)

表单

powder

储存条件

protect from light

颜色

yellow

溶解性

DMSO: ≥10 mg/mL

创始人

Novartis

储存温度

2-8°C

SMILES字符串

[O-][N+](=O)c1ccc(CNc2nc(NCc3cccc(c3)C(F)(F)F)nc4[nH]cnc24)cc1

InChI

1S/C20H16F3N7O2/c21-20(22,23)14-3-1-2-13(8-14)10-25-19-28-17(16-18(29-19)27-11-26-16)24-9-12-4-6-15(7-5-12)30(31)32/h1-8,11H,9-10H2,(H3,24,25,26,27,28,29)

InChI key

DDSBPUYZPWNNGH-UHFFFAOYSA-N

生化/生理作用

TNP是一种有效的选择性IP6K抑制剂;选择性较低的IP3K抑制剂。 2002年首次报道了TNP作为肌醇三磷酸(IP3)激酶抑制剂的发现,但是,最近的参考资料显示TNP作为IP6K抑制剂更有效,这使其对于肌醇焦磷酸盐的研究具有重要意义。
有效和选择性的IP6K抑制剂;选择性较低的IP3K抑制剂。

特点和优势

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单,请单击此处

制备说明

TNP可溶于DMSO,溶解浓度大于等于10 mg/ml。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Toxicology in vitro : an international journal published in association with BIBRA, 48, 342-349 (2018-02-11)
The use of biosolids as a soil conditioner and fertiliser is hindered by the limited knowledge on the risks of micro-contaminants they contain. This study investigated the binding of six organic contaminants commonly found in biosolids, to the estrogen (ER)
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PLoS neglected tropical diseases, 7(8), e2395-e2395 (2013-09-07)
Nematode secreted haemoglobins have unusually high affinity for oxygen and possess nitric oxide deoxygenase, and catalase activity thought to be important in protection against host immune responses to infection. In this study, we generated a monoclonal antibody (48Eg) against haemoglobin
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Medicina (Kaunas, Lithuania), 55(7) (2019-07-10)
Background and objectives: Exercise can help ease withdrawal symptoms of smokers. However, there is little information about the physiological responses, such as cardiorespiratory and lactate (La) responses, during exercise from light to moderate intensity combined with transdermal nicotine patches (TNPs)
Zhoujie Ding et al.
PloS one, 8(11), e81299-e81299 (2013-11-20)
IgM antibodies specific for a certain antigen can enhance antibody responses when administered together with this antigen, a process believed to require complement activation by IgM. However, recent data show that a knock-in mouse strain, Cμ13, which only produces IgM

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