推荐产品
产品名称
3,3′,5,5′-四硫代甲酰乙酸,
溶解性
acetone: soluble 19.60-20.40 mg/mL, clear, colorless (or faintly yellow to yellow)
质量水平
储存温度
−20°C
SMILES字符串
OC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1
InChI
1S/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20)
InChI key
PPJYSSNKSXAVDB-UHFFFAOYSA-N
应用
3,3′,5,5′-四碘甲腺乙酸已被用于：
- 作为阳性对照研究碘苯腈 (IOX)
- 二乙基己烯雌酚 (DES) 暴露对斑马鱼胚胎的影响
- 研究其对聚氨酯麻醉的雄性大鼠齿状回的长期增益 (LTP) 和长期抑制 (LTD) 作用
- 确定其对眼眶成纤维细胞中促甲状腺激素
- 促甲状腺免疫球蛋白的作用的影响。
生化/生理作用
3,3′,5,5′-四碘甲腺乙酸 (Tetrac) 是一种L-甲状腺素 （T4）的 脱氨基类似物。 它可以防止T4和3,5,3′-三碘-L-甲腺原氨酸的促血管生成作用。 它是甲状腺整合素受体的拮抗剂。Tetrac可防止甲状腺激素的结合。
对大鼠的研究报道了 Tetrac 可能在体内条件下调节 TSH 分泌1。
联系
甲状腺激素类似物
制备说明
3,3′,5,5′-四硫代甲基乙酸以 19.60-20.40 mg/ml 溶于丙酮，并形成一种透明的淡黄色至黄色溶液。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
M E Everts et al.
Endocrinology, 136(10), 4454-4461 (1995-10-01)
We compared the uptake, metabolism, and biological effects of tetraiodothyroacetic acid (Tetrac) and rT3 in anterior pituitary cells with those of T4 and T3. Cells were isolated from adult male Wistar rats and cultured for 3 days in medium with
Mary K Luidens et al.
Vascular pharmacology, 52(3-4), 142-145 (2009-11-03)
In models of thyroid hormone-induced cardiac hypertrophy, there is appropriate, supportive angiogenesis. Twenty years ago in one such model, angiogenesis in response to the hormone was observed before hypertrophy developed and it is now understood that iodothyronines induce neovascularization in
Synthesis of new analogs of tetraiodothyroacetic acid (tetrac) as novel angiogenesis inhibitors for treatment of cancer
Rajabi M, et al.
Bioorganic & Medicinal Chemistry Letters, 28(7), 1223-1227 (2018)
Elevated serum tetrac in Graves disease: potential pathogenic role in thyroid-associated ophthalmopathy
Fernando R, et al.
The Journal of clinical endocrinology and metabolism, 102(3), 776-785 (2016)
Tetrac and NDAT induce Anti-proliferation via Integrin alphavbeta3 in Colorectal Cancers with Different K-RAS Status
Chin YT, et al.
Frontiers in Endocrinology, 10, 130-130 (2019)
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