product name
3,3′,5,5′-四硫代甲酰乙酸,
溶解性
acetone: soluble 19.60-20.40 mg/mL, clear, colorless (or faintly yellow to yellow)
质量水平
储存温度
−20°C
SMILES字符串
OC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1
InChI
1S/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20)
InChI key
PPJYSSNKSXAVDB-UHFFFAOYSA-N
应用
3,3′,5,5′-四碘甲腺乙酸已被用于：
- 作为阳性对照研究碘苯腈 (IOX)
- 二乙基己烯雌酚 (DES) 暴露对斑马鱼胚胎的影响
- 研究其对聚氨酯麻醉的雄性大鼠齿状回的长期增益 (LTP) 和长期抑制 (LTD) 作用
- 确定其对眼眶成纤维细胞中促甲状腺激素
- 促甲状腺免疫球蛋白的作用的影响。
生化/生理作用
3,3′,5,5′-四碘甲腺乙酸 (Tetrac) 是一种L-甲状腺素 （T4）的 脱氨基类似物。 它可以防止T4和3,5,3′-三碘-L-甲腺原氨酸的促血管生成作用。 它是甲状腺整合素受体的拮抗剂。Tetrac可防止甲状腺激素的结合。
对大鼠的研究报道了 Tetrac 可能在体内条件下调节 TSH 分泌1。
联系
甲状腺激素类似物
制备说明
3,3′,5,5′-四硫代甲基乙酸以 19.60-20.40 mg/ml 溶于丙酮，并形成一种透明的淡黄色至黄色溶液。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 2 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
Shaker A Mousa et al.
Angiogenesis, 11(2), 183-190 (2007-12-18)
Thyroid hormone has been recently shown to induce tumor growth and angiogenesis via a plasma-membrane hormone receptor on integrin alphaVbeta3. The receptor is at or near the Arg-Gly-Asp (RGD) recognition site on the integrin that is important to extracellular matrix
The Effects of Intra-hippocampal L-thyroxine Infusion on Long-term Potentiation and Long-term Depression: A Possible Role for the avb3 Integrin Receptor
Bitiktas S, et al.
Journal of Neuroscience Research (2016)
M Yalcin et al.
The Journal of clinical endocrinology and metabolism, 95(4), 1972-1980 (2010-02-06)
Tetraiodothyroacetic acid (tetrac) blocks angiogenic and tumor cell proliferation actions of thyroid hormone initiated at the cell surface hormone receptor on integrin alphavbeta3. Tetrac also inhibits angiogenesis initiated by vascular endothelial growth factor and basic fibroblast growth factor. We tested
Tetrac and NDAT induce Anti-proliferation via Integrin alphavbeta3 in Colorectal Cancers with Different K-RAS Status
Chin YT, et al.
Frontiers in Endocrinology, 10, 130-130 (2019)
Paul J Davis et al.
Annual review of pharmacology and toxicology, 51, 99-115 (2010-09-28)
Plasma membrane integrin αvβ3 is a cell surface receptor for thyroid hormone at which nongenomic actions are initiated. L-thyroxine (T₄) and 3,3',5-triiodo-L-thyronine (T₃) promote angiogenesis and tumor cell proliferation via the receptor. Tetraiodothyroacetic acid (tetrac), a deaminated T₄ derivative, blocks
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