T3577
Tolperisone 盐酸盐
≥98% (HPLC), ion channel blocker , solid
别名:
2-Methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one 盐酸盐
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关于此项目
经验公式（希尔记法）:
C16H23NO · HCl
化学文摘社编号:
分子量:
281.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
222-876-5
MDL number:
产品名称
Tolperisone 盐酸盐, ≥98% (HPLC), solid
InChI
1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H
InChI key
ZBUVYROEHQQAKL-UHFFFAOYSA-N
SMILES string
Cl.CC(CN1CCCCC1)C(=O)c2ccc(C)cc2
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: >20 mg/mL
storage temp.
room temp
Quality Level
相关类别
Biochem/physiol Actions
Tolperisone is an ion channel blocker and centrally acting muscle relaxant.
Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.
Tolperisone regulates ionic currents in myelinates axons and subsequently decreases excitability and mediates its antispastic functions3.
Preparation Note
Tolperisone hydrochloride dissolves in water at a concentration that is greater than 20 mg/ml.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Tolperisone: a typical representative of a class of centrally acting muscle relaxants with less sedative side effects
Quasthoff S, et al.
CNS Neuroscience & Therapeutics, 14(2), 107-119 (2008)
D Hinck et al.
General physiology and biophysics, 20(4), 413-429 (2002-05-07)
The actions of tolperisone on single intact Ranvier nodes of the toad Xenopus were investigated by means of the Hodgkin-Huxley formalism. Adding tolperisone to the bathing medium (100 micromol/l) caused the following fully reversible effects: 1. The sodium permeability P'Na
HPLC determination of tolperisone in human plasma
Bae JW, et al.
Archives of Pharmacal Research, 29(4), 339-342 (2006)
A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke
Stamenova P, et al.
European Journal of Neurology, 12(6), 453-461 (2005)
Doris Hofer et al.
European journal of pharmacology, 538(1-3), 5-14 (2006-05-03)
The specific, acute interaction of tolperisone, an agent used as a muscle relaxant and for the treatment of chronic pain conditions, with the Na(v1.2), Na(v1.3), Na(v1.4), Na(v1.5), Na(v1.6), Na(v1.7), and Na(v1.8) isoforms of voltage dependent sodium channels was investigated and
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Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.
电压门控钠通道存在于大多数可兴奋细胞膜中，在产生动作电位方面起着重要作用。
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