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Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
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安全信息

T3258

Sigma-Aldrich

四环素

98.0-102.0% (HPLC)

别名:

Tetracycline Hydrate

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About This Item

经验公式（希尔记法）:
C22H24N2O8 · xH2O
CAS号:
60-54-8
分子量:
444.43 (anhydrous basis)
Beilstein:
2230417
EC 号:
200-481-9
MDL编号:
MFCD00151232
UNSPSC代码:
51284017
PubChem化学物质编号:
24900120
NACRES:
NA.85

质量水平

200

方案

98.0-102.0% (HPLC)

表单

powder or crystals

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

颜色

faint yellow to dark yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

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215619GF46525620GF38907221
硅 powder, −60 mesh, 99.998% trace metals basis

267414

硅

硅 powder, −325 mesh, 99% trace metals basis

215619

硅

硅 powder, max. particle size 45 micron, weight 50 g, high purity 99.998%

GF46525620

硅

硅 powder, max. particle size 150 micron, weight 100 g, purity 97.5%

GF38907221

硅

assay

99.998% trace metals basis

assay

99% trace metals basis

assay

99.998%

assay

97.5%

bp

2355 °C (lit.)

bp

2355 °C (lit.)

bp

2355 °C (lit.)

bp

2355 °C (lit.)

mp

1410 °C (lit.)

mp

1410 °C (lit.)

mp

1410 °C (lit.)

mp

1410 °C (lit.)

density

2.33 g/mL at 25 °C (lit.)

density

2.33 g/mL at 25 °C (lit.)

density

2.33 g/mL at 25 °C (lit.)

density

2.33 g/mL at 25 °C (lit.)

particle size

−60 mesh

particle size

−325 mesh

particle size

-

particle size

-

一般描述

Chemical structure: tetracycline

生化/生理作用

作用机制：四环素通过细胞膜中的 proin 通道被动扩散，与 30S 核糖体结合，并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合，改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用，这表明起到抗菌作用的是可逆结合的抗生素，而不是不可逆结合的药物。

耐药性机制：这种作用通过细胞壁通透性的丧失而失活。

抗菌谱：包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

其他说明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

警示用语：

Warning

危险声明

H302,H361fd,H411

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000395333
    0000380024
    0000350215
    0000312689
    0000319884

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    Maulik Thaker et al.
    Cellular and molecular life sciences : CMLS, 67(3), 419-431 (2009-10-29)
    Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome.
    Lucia Pallecchi et al.
    Antimicrobial agents and chemotherapy, 51(8), 2720-2725 (2007-06-06)
    A survey carried out in 2005 among members of a healthy population of children living in Bolivia and Peru revealed that fecal carriage of Escherichia coli strains resistant to expanded-spectrum cephalosporins was remarkably increased compared to that observed in the
    Jennifer M Adams-Haduch et al.
    Antimicrobial agents and chemotherapy, 52(11), 3837-3843 (2008-08-30)
    A total of 49 unique clinical isolates of multidrug-resistant (MDR) Acinetobacter baumannii identified at a tertiary medical center in Pittsburgh, Pennsylvania, between August 2006 and September 2007 were studied for the genetic basis of their MDR phenotype. Approximately half of
    Vanessa G Allen et al.
    Antimicrobial agents and chemotherapy, 55(2), 703-712 (2010-11-26)
    Surveillance of gonococcal antimicrobial resistance and the molecular characterization of the mechanisms underlying these resistance phenotypes are essential in order to establish correct empirical therapies, as well as to describe the emergence of new mechanisms in local bacterial populations. To
    Zhijie Li et al.
    Proceedings of the National Academy of Sciences of the United States of America, 110(13), 5004-5009 (2013-03-12)
    Reported here is a piggyBac transposon-based expression system for the generation of doxycycline-inducible, stably transfected mammalian cell cultures for large-scale protein production. The system works with commonly used adherent and suspension-adapted mammalian cell lines and requires only a single transfection
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