推荐产品
SMILES字符串
Cl.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(F)(F)F
InChI
1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
InChI key
FTNWXGFYRHWUKG-UHFFFAOYSA-N
基因信息
human ... DRD2(1813)
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应用
Triflupromazine hydrochloride has been used for the screening of inhibitors of S. mansoni miracidial transformation5. It has also been used to study its intracellular localization in central nervous system cells using secondary ion mass spectrometry microscopy6.
生化/生理作用
Triflupromazine is a D2 dopamine antagonist and a phenothiazine antipsychotic. It is also a potent tranquilizer7 and can significantly reduce body temperature8.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
M Tatsumi et al.
European journal of pharmacology, 368(2-3), 277-283 (1999-04-08)
Using radioligand binding techniques, we determined the equilibrium dissociation constants (K(D)) for 37 neuroleptics and one metabolite of a neuroleptic (haloperidol metabolite) for the human serotonin, norepinephrine, and dopamine transporters with [3H]imipramine, [3H]nisoxetine, and [3H]WIN35428, respectively. Among neuroleptics, the four
The structure of triflupromazine, a phenothiazine 'tranquilizer' drug molecule.
Phelps, D. W., and Cordes, A. W.
Acta Crystallographica Section B, Structural Crystallography and Crystal Chemistry, 30(12), 2812-2816 (1974)
L L Zhang et al.
Biology of the cell, 74(1), 99-103 (1992-01-01)
The intracellular localization of two neurotropic drugs, flunitrazepam (benzodiazepine) and triflupromazine (phenothiazine), was studied by secondary ion mass spectrometry microscopy (SIMS) in three varieties of cells. The images of the intracellular distributions of the two drugs are easily obtained by
A study of triflupromazine in dominant-lethal, cytogenetic and host-mediated assays.
V A Ray et al.
Mutation research, 18(3), 301-309 (1973-06-01)
D Jovanović-Mićić et al.
European journal of pharmacology, 272(1), 21-30 (1995-01-05)
Intracerebroventricular injection of dopamine (0.5-4.0 mg) produced dose-dependent and short-lasting emesis (1-8 min) in cats, which was abolished after ablation of the area postrema. Relatively selective alpha 2-adrenoceptor antagonists (yohimbine and idazoxan) and a mixed alpha 1- and alpha 2-adrenoceptor
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