推荐产品
产品名称
7-Ethoxy-4-(trifluoromethyl)coumarin, ≥98% (TLC)
质量水平
方案
≥98% (TLC)
表单
powder
溶解性
chloroform: 100 mg/mL, clear, colorless (Soluble in chloroform, methanol, and DMSO.)
荧光
λex 333 nm; λem 415 nm in methanol
储存温度
−20°C
SMILES字符串
CCOc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
InChI
1S/C12H9F3O3/c1-2-17-7-3-4-8-9(12(13,14)15)6-11(16)18-10(8)5-7/h3-6H,2H2,1H3
InChI key
OLHOIERZAZMHGK-UHFFFAOYSA-N
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特点和优势
7-Ethoxy-4-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P-450 catalyzed O-de-ethylation.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
J G DeLuca et al.
Biochemical pharmacology, 37(9), 1731-1739 (1988-05-01)
The microsomal O-deethylation of a novel coumarin analog, 7-ethoxy-4-trifluoromethylcoumarin (EFC), to a fluorescent product was characterized. Results indicate that this analog provides a rapid, convenient and highly sensitive means to assay cytochrome P-450-mediated metabolism. Like microsomal 7-ethoxycoumarin (7-EC) O-deethylation, EFC
Thomas Van Leeuwen et al.
Pest management science, 62(5), 425-433 (2006-03-22)
Tetranychus urticae Koch has recently developed resistance to chlorfenapyr in Australia and Japan, but no attempt has yet been made to describe the biochemical mechanisms involved in chlorfenapyr resistance. In this study a laboratory-selected chlorfenapyr-resistant strain was investigated. Resistance to
Maori Mitsuda et al.
Protein expression and purification, 46(2), 401-405 (2005-11-29)
Improvement of CYP2B6 expression was examined by co-expression with molecular chaperones GroES/EL. Although a CO-reduced difference spectrum was not detected in Escherichia coli transformed only by the CYP2B6-expressing vector, co-expression of GroES/EL resulted in high-level expression which reached over 2000
Shih-Feng Lan et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(4), 1314-1323 (2010-02-23)
In this study, we have evaluated the use of ultra-sterile alginate hydrogels encapsulated with HepG2 liver cells for applications in high throughput drug screening. We have studied the cellular viability and metabolic capacity of the encapsulated cells in two different
Xilin Li et al.
Toxicological sciences : an official journal of the Society of Toxicology, 175(2), 251-265 (2020-03-12)
Metabolism plays a key role in chemical genotoxicity; however, most mammalian cells used for in vitro genotoxicity testing lack effective metabolizing enzymes. We recently developed a battery of TK6-derived cell lines that individually overexpress 1 of 8 cytochrome P450s (CYP1A1
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