T2752
3,3′,5-三碘-L-甲状腺氨酸 钠盐
≥95% (HPLC)
别名:
O-（4-羟基-3-碘苯基）-3,5-二碘-L-酪氨酸 钠盐, T3, 碘塞罗宁
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关于此项目
经验公式（希尔记法）:
C15H11I3NNaO4
化学文摘社编号:
分子量:
672.96
UNSPSC Code:
51111800
NACRES:
NA.32
PubChem Substance ID:
EC Number:
200-223-5
Beilstein/REAXYS Number:
8179867
MDL number:
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥95% (HPLC)
产品名称
3,3′,5-三碘-L-甲状腺氨酸 钠盐, ≥95% (HPLC)
InChI key
SBXXSUDPJJJJLC-YDALLXLXSA-M
InChI
1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
SMILES string
[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
biological source
synthetic (organic)
assay
≥95% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to faintly yellow or pink
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)
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Application
3,3′,5-Triiodo-L-thyronine sodium salt was used in Oligodendrocyte differentiation medium used for isolation and culture of rat and mouse oligodendrocyte precursor cells. The product was used as a test compound for incubating adipocyte cells, used for studying the impact of hormones and butyrate on modulation of porcine adipocyte beta-adrenergic receptors.
Biochem/physiol Actions
3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)−3,5−diiodo-L-tyrosine sodium salt or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine can enhance mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation.
Preparation Note
3,3′,5-Triiodo-L-thyronine sodium salt dissolves in 1 M HCl:EtOH with a ratio of 1:4 at 10 mg/ml to yield a clear, colorless to yellow or faint pink solution.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Radim Vrzal et al.
Toxicology letters, 275, 77-82 (2017-05-10)
Aryl hydrocarbon receptor (AhR) is a transcription factor, the activity of which is modulated by hormones including glucocorticoids and estrogens. In this study, we examined the effects of triiodothyronine (T3), a ligand and activator of thyroid hormone receptor (TR), on
Ye-Seul Yoon et al.
Biomolecules & therapeutics, 29(1), 83-89 (2020-06-17)
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by presence of α-synuclein-positive inclusions in the cytoplasm of oligodendrocytes. These glial cytoplasmic inclusions (GCIs) are considered an integral part of the pathogenesis of MSA, leading to demyelination and neuronal demise.
S T Ding et al.
Journal of animal science, 78(4), 927-933 (2000-04-28)
The beta-adrenergic receptors (betaAR) on the surface of mammalian cells are desensitized when the cell is stimulated by betaAR agonists to eliminate excessive response by the cell. Investigations with adipocytes, primarily rodent-derived cells, indicate other hormones and substrates also can
Nicolas Buisine et al.
Cells, 10(9) (2021-09-29)
Most work in endocrinology focus on the action of a single hormone, and very little on the cross-talks between two hormones. Here we characterize the nature of interactions between thyroid hormone and glucocorticoid signaling during Xenopus tropicalis metamorphosis. We used
Kevin W Jackman et al.
Aquatic toxicology (Amsterdam, Netherlands), 202, 46-56 (2018-07-15)
Thyroid hormones (THs) regulate vertebrate growth, development, and metabolism. Despite their importance, there is a need for effective detection of TH-disruption by endocrine disrupting chemicals (EDCs). The frog olfactory system substantially remodels during TH-dependent metamorphosis and the objective of the
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