T2576
Monoclonal Anti-TIS7 antibody produced in mouse
~2 mg/mL, clone IRT537, purified immunoglobulin, buffered aqueous solution
别名:
Anti-Interferon-Related Developmental Regulator 1 (IFRD1) (human), Anti-PC4 (rat), Anti-TPA-Induced Sequence 7 (mouse)
产品名称
Monoclonal Anti-TIS7 antibody produced in mouse, ~2 mg/mL, clone IRT537, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
IRT537, monoclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
mouse, human
concentration
~2 mg/mL
technique(s)
immunocytochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.25-0.5 using extracts of COS7 cells transfected with mouse Tis7
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IFRD1(3475)
mouse ... Ifrd1(15982)
rat ... Ifrd1(29596)
Application
Monoclonal Anti-TIS7 antibody produced in mouse has been used in western blot analysis.
Biochem/physiol Actions
Tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7)/interferon related developmental regulator 1(FRD1) is implicated in regulation of the proliferation and differentiation pathways induced by nerve growth factor (NGF). The encoded protein also plays a vital role in myocyte differentiation, and it modulates the nuclear factor-κB (NF-κB) pathway by influencing the activity of histone deacetylases and forming complexes with the p65 subunit of NFκB. Genetic variations in the gene is associated with the development of various diseases such as sensory/motor neuropathy with ataxia (SMNA), cystic fibrosis, lung disease and myelodysplastic syndrome (MDS). TIS7 is also implicated in regulation of airway inflammation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
The tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7), also known as interferon related developmental regulator 1 (FRD1), is mapped to human chromosome 7q31.1. The gene with 13 exons, spans about 52kb of genomic DNA. The encoded protein consists of 451 amino acids and is expressed in mature neutrophils.
Immunogen
synthetic peptide corresponding to amino acids 30-47 of mouse Tis7, conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The IFRD1 (57460C>T Polymorphism) Gene: A Negative Report in Cystic Fibrosis Clinical Severity
de Lima Marson
Journal of Molecular and Genetic Medicine, 7, 2-8 (2013)
PC4/Tis7/IFRD1 stimulates skeletal muscle regeneration and is involved in myoblast differentiation as a regulator of MyoD and NF-kappaB
Micheli L, et al.
Test, 286(7), 5691-5707 (2011)
Mutated genes and driver pathways involved in myelodysplastic syndromes?a transcriptome sequencing based approach.
Liu L
Molecular Biosystems, 11, 2158-2166 (2015)
IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23.
Brkanac Z
American Journal of Human Genetics, 84, 692-697 (2009)
Bart Tummers et al.
Nature communications, 6, 6537-6537 (2015-06-10)
High-risk human papillomaviruses (hrHPVs) infect keratinocytes and successfully evade host immunity despite the fact that keratinocytes are well equipped to respond to innate and adaptive immune signals. Using non-infected and freshly established or persistent hrHPV-infected keratinocytes we show that hrHPV
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