所有图片(1)
About This Item
经验公式（希尔记法）:
C6H11NO4
CAS号:
分子量:
161.16
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
形式
powder
质量水平
颜色
white to off-white
溶解性
H2O: >1.5 mg/dL
适用性
suitable for TLC (single spot)
储存温度
room temp
SMILES字符串
C[C@@H](CC(O)=O)[C@@H](N)C(O)=O
InChI
1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1
InChI key
FHJNAFIJPFGZRI-WVZVXSGGSA-N
生化/生理作用
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.
特点和优势
This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
制备说明
T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Lois Slator et al.
Journal of aerosol medicine and pulmonary drug delivery, 27 Suppl 1, S37-S43 (2014-01-31)
Valved holding chambers (VHCs) are accessory devices for pressurized metered dose inhalers (pMDIs). Use of a VHC may help overcome coordination issues associated with drug delivery via the pMDI alone. Previous work has established that aspects of VHC use, including
Guide to Receptors and Channels (GRAC), 4th Edition.
British journal of pharmacology, 158 Suppl 1, S1-254 (2009-11-04)
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