T2000
睾酮β-D-葡糖苷酸
别名:
17β-Hydroxy-4-androsten-3-one 17-D-glucuronide, 4-Androsten-17β-ol-3-one 17-glucuronide
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关于此项目
经验公式（希尔记法）:
C25H36O8
化学文摘社编号:
分子量:
464.55
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CC12CCC3C(CCC4=CC(=O)CCC34C)C1CCC2OC5OC(C(O)C(O)C5O)C(O)=O
drug control
USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
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Application
Testosterone has been used as a substrate for UDP-glucuronyltransferase based drug metabolism assays using microsome-encapsulation techniques.
Biochem/physiol Actions
Androgens direct the development of the male phenotype during embryogenesis and at puberty. Testosterone is an androgen that is secreted by the testis. This hormone is converted to dihydrotestosterone in the target tissues where it appears to mediate several biological functions.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
L Di Luigi et al.
Journal of endocrinological investigation, 32(5), 445-453 (2009-05-23)
To describe serum and urinary hormones, androgens metabolites and testosterone/epitestosterone ratio profiles after testosterone administration in male hypogonadal volunteers, and to evaluate their possible usefulness in detecting doping with testosterone in treated hypogonadal athletes. Controlled open label design vs placebo;
L Dehennin et al.
European journal of endocrinology, 130(1), 53-59 (1994-01-01)
In this cross-sectional study on 140 subjects, several testosterone and epitestosterone metabolites have been analyzed by gas chromatography-mass spectrometry associated with stable isotope dilution, a technique requested for doping analysis in general, and detection of exogenous testosterone supply in particular.
Genetic variations in UDP-glucuronosyl transferase 2B17: implications for testosterone excretion profiling and doping control programs.
Borislav Starcevic et al.
Clinical chemistry, 54(12), 1945-1947 (2008-10-18)
E Palonek et al.
The Journal of steroid biochemistry and molecular biology, 55(1), 121-127 (1995-10-01)
In an attempt to find optimal markers of exogenous testosterone (T) administration in male athletes, a number of compounds were measured in 11 healthy men before and after 3, 6 and 9 months of weekly administration of 250 mg i.m.
L Dehennin
The Journal of endocrinology, 142(2), 353-360 (1994-08-01)
Testosterone administration to male athletes can be safely detected in the vast majority of cases by the urinary excretion ratio of testosterone to epitestosterone glucuronides (TG/EG), which may not exceed 6. Some rare cases of physiologically high TG/EG ratios (between
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