生物来源
Streptomyces sp.
质量水平
检测方案
≥98% (HPLC)
形式
DMSO solution
浓度
5 mM in DMSO
技术
cell culture | mammalian: suitable
抗生素抗菌谱
fungi
neoplastics
作用机制
enzyme | inhibits
运输
dry ice
储存温度
−20°C
InChI
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+
InChI key
RTKIYFITIVXBLE-WKWSCTOISA-N
一般描述
曲古抑菌素A是一种一级羟肟酸。
应用
曲古抑菌素A即用型溶液已用于：
- 作为组蛋白去乙酰化酶抑制剂，通过干细胞试验研究其对转录组变化的影响
- 抑制原代垂体细胞培养物中的I、II或III类组蛋白去乙酰化酶(HDAC)，用于研究内源性人生长激素基因(hGH)的胰岛素调节
- 处理细胞进行HDAC抑制实验
生化/生理作用
曲古抑菌素 A (Trichostatin A，TSA) 是一种 链霉菌 代谢产物，在纳摩尔浓度下特异性抑制哺乳动物组蛋白去乙酰化酶，引起哺乳动物细胞内高度乙酰化的组蛋白分子积累。因此，曲古抑菌素 A 可用作研究体内组蛋白乙酰化的工具。曲古抑菌素 A 诱导细胞分化、细胞周期阻滞、逆转转化细胞形态和凋亡，并能够调节转录。TSA 已被用于建立一种新的克隆技术，从而提高了小鼠克隆的成功率。
相关产品
产品编号
说明
价格
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Negative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells
Vakili H, et al.
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Current medicinal chemistry, 11(12), 1629-1643 (2004-06-08)
Modulation of chromatin structure through histone acetylation/deacetylation is known to be one of the major mechanisms involved in the regulation of gene expression. Two opposing enzyme activities determine the acetylation state of histones: histone acetyltransferases (HATs) and histone deacetylases (HDACs)
Valentina Saccone et al.
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Fibro-adipogenic progenitors (FAPs) are important components of the skeletal muscle regenerative environment. Whether FAPs support muscle regeneration or promote fibro-adipogenic degeneration is emerging as a key determinant in the pathogenesis of muscular diseases, including Duchenne muscular dystrophy (DMD). However, the
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