T1952
Trichostatin A, Ready Made Solution
5 mM in DMSO, from Streptomyces sp.
别名:
TSA, [R-(E,E)]-7-[4-（二甲氨基）苯基]-N-羟基-4,6-二甲基-7-氧代-2,4-庚二烯酰胺, 曲古抑菌素 A，预制溶液
产品名称
Trichostatin A, Ready Made Solution, 5 mM in DMSO, from Streptomyces sp.
SMILES string
N(O)C(=O)\C=C\C(=C\C(C)C(=O)c1ccc(cc1)N(C)C)\C
InChI
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+
InChI key
RTKIYFITIVXBLE-WKWSCTOISA-N
biological source
Streptomyces sp.
assay
≥98% (HPLC)
form
DMSO solution
concentration
5 mM in DMSO
technique(s)
cell culture | mammalian: suitable
antibiotic activity spectrum
fungi
neoplastics
mode of action
enzyme | inhibits
shipped in
dry ice
storage temp.
−20°C
Quality Level
General description
曲古抑菌素A是一种一级羟肟酸。
Application
曲古抑菌素A即用型溶液已用于：
- 作为组蛋白去乙酰化酶抑制剂，通过干细胞试验研究其对转录组变化的影响
- 抑制原代垂体细胞培养物中的I、II或III类组蛋白去乙酰化酶(HDAC)，用于研究内源性人生长激素基因(hGH)的胰岛素调节
- 处理细胞进行HDAC抑制实验
Biochem/physiol Actions
曲古抑菌素 A (Trichostatin A，TSA) 是一种 链霉菌 代谢产物，在纳摩尔浓度下特异性抑制哺乳动物组蛋白去乙酰化酶，引起哺乳动物细胞内高度乙酰化的组蛋白分子积累。因此，曲古抑菌素 A 可用作研究体内组蛋白乙酰化的工具。曲古抑菌素 A 诱导细胞分化、细胞周期阻滞、逆转转化细胞形态和凋亡，并能够调节转录。TSA 已被用于建立一种新的克隆技术，从而提高了小鼠克隆的成功率。
曲古抑菌素 A 是一种链霉菌代谢产物，特异性抑制哺乳动物组蛋白去乙酰化酶。
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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