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生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
pig
技术
immunohistochemistry: 15 μg/mL
indirect ELISA: 0.5-1.0 μg/mL
neutralization: suitable
western blot: 0.1-0.2 μg/mL
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
pig ... TNF(397086)
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一般描述
Tumor Necrosis Factor-α (TNF-α) also refers as cachectin is a cytokine produced in response to immunological challenges such as bacteria (lipopolysaccharides), parasites, mitogens, viruses and other cytokines. It has essential roles in antitumor activity, inflammation, septic shock, immune modulation, anorexia, cachexia, hematopoiesis and viral replication. It also facilitates the growth of human fibroblasts, collagenase production as well as can activates polymorphonuclear neutrophils and osteoclasts. Anti-Tumor Necrosis Factor-α antibody can be used in neutralization and immunoblotting (working concentration-0.1-0.2 μg/ml) for detecting porcine TNF-α. Goat anti-Tumor Necrosis Factor-α antibody reacts specifically with recombinant porcine tumor necrosis factor α.
特异性
The antibody neutralizes the biological activity of recombinant porcine TNF-α.
免疫原
recombinant porcine TNF-α expressed in Escherichia coli.
应用
Anti-Tumor Necrosis Factor-α antibody can be used in immunohistochemistry and indirect ELISA.
外形
Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
法规信息
新产品
Molecular medicine reports, 13(2), 1250-1256 (2015-12-10)
Complement anaphylatoxins have been investigated extensively; however, the role of complement anaphylatoxin C4a in hyperoxic lung injury has yet to be investigated. To the best of our knowledge, the present study is the first to demonstrate the role of C4a
Nature, 319(6053), 516-518 (1986-02-06)
When leukocytes are exposed to mitogens or antigens in vitro, they release bone-resorbing activity into the culture supernatants which can be detected by bioassay. Like many lymphocyte-monocyte products, this activity has been difficult to purify because of its low abundance
The Journal of experimental medicine, 162(6), 2163-2168 (1985-12-01)
Cachectin/TNF (tumor necrosis factor), an endotoxin-induced murine macrophage hormone implicated in the pathogenesis of cachexia and shock, has been found capable of stimulating collagenase and prostaglandin E2 (PGE2) production by isolated human synovial cells and dermal fibroblasts. This bioactivity associated
Science (New York, N.Y.), 230(4728), 943-945 (1985-11-22)
Modulation of the growth of human and murine cell lines in vitro by recombinant human tumor necrosis factor-alpha (rTNF-alpha) and recombinant human interferon-gamma (rIFN-gamma) was investigated. rTNF-alpha had cytostatic or cytolytic effects on only some tumor cell lines. When administered
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