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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~43 kDa
种属反应性
human, rat, mouse
浓度
~1.5 mg/mL
技术
immunohistochemistry: 5-10 μg/mL using rat, mouse or human kidney
indirect immunofluorescence: 5-10 μg/mL using human HepG2 cells
western blot: 1.5-3.0 μg/mL using human U2OS cell lysates
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TARDBP(23435)
一般描述
TDP-43 (TAR DNA binding protein, TARDP) is encoded by the gene mapped to human chromosome 1p36.22. The encoded protein belongs to the family of heterogenous nuclear ribonucleoproteins (hnRNPs) that bind single stranded RNA. TDP-43 is a 414 amino acid nuclear protein and is widely expressed in a variety of tissues.
特异性
Anti-TDP-43 specifically recognizes human, mouse, and rat TDP-43.
生化/生理作用
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are involved in the generation and processing of RNA, including transcription, splicing, transport and stability. TDP-43 regulates transcription of human immunodeficiency virus (HIV). The protein is identified as a major pathological protein, in both frontotemporal lobe degeneration subtype (FTLD-U) and amyotrophic lateral sclerosis (ALS). Abnormal phosphorylation of TDP-43 at Ser409/410 has also been observed in FTLD-U and ALS, suggesting a toxic gain of function leading to apoptosis.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
储存及稳定性
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Miao Sun et al.
Journal of neuroscience research, 92(1), 54-63 (2013-11-23)
The 43-kDa transactivation response DNA binding protein (TDP43), fused in sarcoma/translocated in liposarcoma (FUS/TLS), heat shock protein 70 (HSP70), and β-amyloid (Aβ) are induced and involved in cerebral ischemia, amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD), but their relationships
Matthew J G Eldridge et al.
PLoS pathogens, 17(12), e1010173-e1010173 (2021-12-21)
For many intracellular bacterial pathogens manipulating host cell survival is essential for maintaining their replicative niche, and is a common strategy used to promote infection. The bacterial pathogen Listeria monocytogenes is well known to hijack host machinery for its own
The role of TDP-43 in amyotrophic lateral sclerosis and frontotemporal dementia
Mackenzie, Ian RA and Rademakers, Rosa
Current Opinion in Neurology, 21(6), 693-693 (2008)
TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression
Ayala YM, et al.
Proceedings of the National Academy of Sciences, 105(10), 3785-3789 (2008)
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS
Inukai Y, et al.
Febs Letters, 582(19), 2899-2904 (2008)
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