推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to tan
溶解性
DMSO: ≥20 mg/mL
创始人
Servier
储存温度
room temp
SMILES字符串
O.[Na+].CN1c2ccccc2C(NCCCCCCC([O-])=O)c3ccc(Cl)cc3S1(=O)=O
InChI
1S/C21H25ClN2O4S.Na.H2O/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);;1H2/q;+1;/p-1
InChI key
HNTRDGDHBBFLPG-UHFFFAOYSA-M
一般描述
噻奈普汀是一种μ-阿片受体（MOR）和δ-阿片受体（DOR）激动剂。
应用
水合噻奈普汀钠盐已被用于在人胚肾293细胞系中进行的5-羟色胺转运体（SERT）测定中作为5-羟色胺再摄取增强剂（SSRE）阳性对照。
生化/生理作用
噻奈普汀是一种可增强5-羟色胺再摄取的三环类抗抑郁药。这种药物会影响到神经保护、神经兴奋性、记忆和焦虑。然而，噻奈普汀与不良的精神运动、认知、心血管、睡眠和体重影响无关。该药物具有较低的滥用倾向性，以及正向的药代动力学曲线。
噻奈普汀是最少参与到药物相互作用的，因为它并不会被肝脏中的细胞色素P450系统所代谢。在海马体和杏仁核中，噻奈普汀可参与到谷氨酸能传递过程并引起神经可塑性。
制备说明
噻奈普汀钠盐水合物可溶于 DMSO，浓度大于或等于 20 mg/ml。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
M Teresa Donato et al.
Journal of biomolecular screening, 17(3), 394-400 (2011-11-26)
In the present study, we developed a cell-based protocol for the identification of drugs able to induce steatosis. The assay measures multiple markers of toxicity in a 96-well plate format using high-content screening (HCS) technology. After treating HepG2 cells with
Liana Orola et al.
International journal of pharmaceutics, 432(1-2), 50-56 (2012-05-10)
The anti-depressant pharmaceutical tianeptine has been investigated to determine the dynamics of polymorph formation under various pH conditions. By varying the pH two crystalline polymorphs were isolated. The molecular and crystal structures have been determined to identify the two polymorphs.
E Venzala et al.
Psychopharmacology, 224(2), 313-325 (2012-06-19)
Chronic social defeat stress (CSDS) has been proposed as a model of depression. However, most CSDS studies rely only on the analysis of stress-induced social avoidance. Moreover, the predictive validity of the model has been poorly analyzed, let alone its
Oguz Mutlu et al.
Life sciences, 91(25-26), 1252-1262 (2012-10-17)
Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of
B S McEwen et al.
Molecular psychiatry, 10(6), 525-537 (2005-03-09)
Recent studies have provided evidence that structural remodeling of certain brain regions is a feature of depressive illness, and the postulated underlying mechanisms contribute to the idea that there is more to antidepressant actions that can be explained exclusively by
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