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Merck
CN

T1573

Sigma-Aldrich

凝血酶受体活化因子肽 6

>95% (HPLC)

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别名:
TRAP-6
经验公式(希尔记法):
C34H56N10O9
分子量:
748.87
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

>95% (HPLC)

形式

lyophilized

技术

cell culture | mammalian: suitable

溶解性

0.1% TFA: soluble
water: soluble

UniProt登记号

储存温度

−20°C

SMILES字符串

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1

InChI key

HAGOWCONESKMDW-FRSCJGFNSA-N

基因信息

human ... F2R(2149)

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn

一般描述

凝血酶受体激活肽6(TRAP-6)可保护星形胶质细胞免于细胞死亡,其与低血糖症有关。在流动条件下,TRAP-6会诱导聚集并损害胶原蛋白的附着力。

应用

凝血酶受体激活物肽6已在体外被用于激活血小板。它也已被用于下调hippo信号并上调核yes相关蛋白(YAP)。

生化/生理作用

凝血酶受体的六肽片段(残基 42-47)。可激活凝血酶受体并引起血小板聚集 (EC 50 = 0.8 μM)。

其他说明

从 0.1%TFA 水溶液冻干

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

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