所有图片(1)
About This Item
经验公式（希尔记法）:
C12H10FN3O2S
CAS号:
分子量:
279.29
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to light brown
溶解性
DMSO: 5 mg/mL, clear
创始人
GlaxoSmithKline
储存温度
2-8°C
SMILES字符串
NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2
InChI
1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
InChI key
SAYGKHKXGCPTLX-UHFFFAOYSA-N
应用
TPCA-1已用于研究其在RPMI8226和LP1细胞系中的细胞毒性作用。它还可作为培养基补充剂，用于从人气道平滑肌细胞中提取的核蛋白组分。
生化/生理作用
IKK-2抑制剂
TPCA-1是人IκB激酶-2（IKK-2）的一种有效选择性抑制剂，对于IKK-2的IC50 = 17.9 nM，而相比之下IKK-1为400 nm。它已用于研究IKK-2的抑制以防止炎症介质在关节炎和气道炎症动物模型中的释放。
特点和优势
该化合物由 GlaxoSmithKline 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
制备说明
TPCA-1可以大于或等于10 mg/ml的浓度溶于DMSO。它不可溶于水。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-B.
Zha, W. J., et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2013, doi:10-doi:10 (2013)
Y Gao et al.
Oncogenesis, 6(9), e383-e383 (2017-09-26)
Clinical and experimental evidence indicates that macrophages could promote solid-tumor progression and metastasis. However, the mechanisms underlying this process remain unclear. Here we show that yes-associated protein 1 (YAP1), a transcriptional regulator that controls tissue growth and regeneration, has an
Patricia L Podolin et al.
The Journal of pharmacology and experimental therapeutics, 312(1), 373-381 (2004-08-19)
Demonstration that IkappaB kinase 2 (IKK-2) plays a pivotal role in the nuclear factor-kappaB-regulated production of proinflammatory molecules by stimuli such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 suggests that inhibition of IKK-2 may be beneficial in the treatment
Ines Tagoug et al.
PloS one, 6(7), e22641-e22641 (2011-07-30)
Multiple myeloma (MM) is a B cell neoplasm characterized by bone marrow infiltration with malignant plasma cells. IGF-1 signalling has been explored as a therapeutic target in this disease. We analyzed the effect of the IKK2 inhibitor AS602868, in combination
Lauren D Aarreberg et al.
mBio, 9(2) (2018-03-22)
Induction of interferon beta (IFN-β), IFN-stimulated genes (ISGs), and inflammatory responses is critical for control of viral infection. We recently identified an essential linkage of stimulation of the inflammatory cytokine interleukin-1β (IL-1β) and induction of ISGs that function as host
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门