T1443
TCPOBOP
≥98% (HPLC), CAR agonist, solid
别名:
1,4-双-[2-（3,5-二氯吡啶氧基）] 苯, 3,3′,5,5′-四氯-1,4-双（吡啶氧基）苯
登录 查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C16H8N2O2Cl4
化学文摘社编号:
分子量:
402.06
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
TCPOBOP, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: >10 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
Clc1cnc(Oc2ccc(Oc3ncc(Cl)cc3Cl)cc2)c(Cl)c1
InChI
1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H
InChI key
BAFKRPOFIYPKBQ-UHFFFAOYSA-N
基因信息
human ... NR1I3(9970)
应用
TCPOBOP 已被用于增强小鼠肝癌细胞中 Mcl-1-斜体启动子的功能。TCPOBOP 也被用于研究组成型雄烷受体 (CAR) 诱导小鼠肝细胞基因表达。
生化/生理作用
TCPOBOP 作为 CAR 的剂量依赖性直接激动剂，可增强细胞色素 P450 (CYP) 的核受体 CAR 转活。
TCPOBOP 作为 CAR 的剂量依赖性直接激动剂，可增强细胞色素 P450 (CYP) 的核受体 CAR 转活。是苯巴比妥类 CYP 诱导剂中已知最有效的成分。
特点和优势
该化合物是细胞凋亡研究的特色产品。点击此处，发现更多特色细胞凋亡产品。如需了解有关生物活性小分子在其他研究领域的更多信息，请访问sigma.com/ discover-bsm。
制备说明
TCPOBOP 可溶于 DMSO，浓度大于 10 mg/mL。不溶于水。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Christopher Reed et al.
The American journal of pathology, 184(6), 1853-1859 (2014-04-15)
Diverse etiologic events are associated with the development of hepatocellular carcinoma. During hepatocarcinogenesis, genetic events likely occur that subsequently cooperate with long-term exposures to further drive the progression of hepatocellular carcinoma. In this study, the frequent loss of the retinoblastoma
Albert Braeuning et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(5), 1138-1145 (2009-02-25)
Basal as well as xenobiotic-induced expression of the main enzymes from phase I and phase II of drug metabolism is confined to the perivenous areas of the mammalian liver lobule. Whereas signal transduction pathways that govern xenobiotic-induced expression of these
Nicholas J Lodato et al.
Toxicological sciences : an official journal of the Society of Toxicology, 164(1), 115-128 (2018-04-05)
Activation of the nuclear receptor and transcription factor CAR (Nr1i3) by its specific agonist ligand TCPOBOP (1, 4-bis[2-(3, 5-dichloropyridyloxy)]benzene) dysregulates hundreds of genes in mouse liver and is linked to male-biased hepatocarcinogenesis. To elucidate the genomic organization of CAR-induced gene
Edwina S Baskin-Bey et al.
Hepatology (Baltimore, Md.), 44(1), 252-262 (2006-06-27)
The constitutive androstane receptor (CAR) modulates xeno- and endobiotic hepatotoxicity by regulating detoxification pathways. Whether activation of CAR may also protect against liver injury by directly blocking apoptosis is unknown. To address this question, CAR wild-type (CAR+/+) and CAR knockout
Sana-Kay Whyte-Allman et al.
The Journal of pharmacology and experimental therapeutics, 363(3), 324-335 (2017-10-04)
Poor antiretroviral drug (ARV) penetration in the testes could be due, in part, to the presence of ATP-binding cassette (ABC) membrane-associated drug efflux transporters such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-associated proteins (MRPs) expressed at
商品
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持