biological source
bovine
assay
97-100% (agarose gel electrophoresis)
form
powder
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
bovine ... TF(280705)
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Biochem/physiol Actions
Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.
Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.
General description
Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1.
Analysis Note
经琼脂糖凝胶电泳纯度。
Application
Holo-Transferrin bovine has been used:
- as a RPMI-1640 medium supplement for culturing cancer cell lines
- as a component of visceral fat differentiation medium for the pre-adipocytes primary cell culture
- to test the influence of iron-saturation complex on the growth of Malassezia pachydermatis
- as a standard for strong anion exchange (SAX) reactor measurements
wgk
WGK 3
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
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N P Singh et al.
Life sciences, 70(1), 49-56 (2002-01-05)
Artemisinin becomes cytotoxic in the presence of ferrous iron. Since iron influx is high in cancer cells, artemisinin and its analogs selectively kill cancer cells under conditions that increase intracellular iron concentrations. We report here that after incubation with holotransferrin
Bovine and canine transferrin inhibit the growth of Malassezia pachydermatis in vitro
Bond R, et al.
Medical Mycology, 43(5), 447-451 (2005)
Metabolic restriction of cancer cells in vitro causes karyotype contraction?an indicator of cancer promotion?
Li Y, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 33(1), 195-205 (2012)
A single nucleotide polymorphism in the coding region of bovine transferrin is associated with milk fat yield
Sanz A, et al.
Genetics and molecular research : GMR, 9(2), 843-848 (2010)
Dynamics of iron release from transferrin N-lobe studied by electrospray ionization mass spectrometry
Gumerov DR and Kaltashov IA
Analytical Chemistry, 73(11), 2565-2570 (2001)
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